Gene: LLGL1
Official Full Name: LLGL scribble cell polarity complex component 1provided by HGNC
Gene Summary: This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08554 | LLGL1 Knockout cell line (HeLa) | Human | LLGL1 | 1:3~1:6 | Negative | Online Inquiry |
KO08555 | LLGL1 Knockout cell line (HCT 116) | Human | LLGL1 | 1:2~1:4 | Negative | Online Inquiry |
KO08556 | LLGL1 Knockout cell line (HEK293) | Human | LLGL1 | 1:3~1:6 | Negative | Online Inquiry |
KO08557 | LLGL1 Knockout cell line (A549) | Human | LLGL1 | 1:3~1:4 | Negative | Online Inquiry |
LLGL1 Gene Knockout Cell Lines are engineered cellular models specifically developed to study the functional consequences of the loss of LLGL1 (Lethal giant larvae 1) gene expression in various biological contexts. This gene plays a crucial role in the regulation of cell polarity, proliferation, and differentiation, making LLGL1 knockout cell lines invaluable for probing the underlying mechanisms of tumorigenesis and other pathologies.
The key functionality of these cell lines lies in their ability to accurately mimic the biological effects of LLGL1 deficiency. Through the precise application of CRISPR-Cas9 technology, these cell lines exhibit a stable knockout of the LLGL1 gene, enabling researchers to investigate its role in cellular signaling pathways, tumor suppression, and development. The loss of LLGL1 is associated with disrupted cell adhesion and increased invasiveness, thus providing a dynamic platform for investigative studies into cancer metastasis or developmental biology.
In scientific research and clinical applications, LLGL1 knockout cell lines are paramount for studying complex diseases, notably in oncology. They facilitate high-throughput screening of potential drug candidates that target cellular pathways affected by LLGL1 dysfunction, leading to advancements in therapeutic strategies. Additionally, these models are instrumental in elucidating the biological processes in various tissue types and can be adapted for diverse experimental designs.
Compared to other existing models, LLGL1 knockout cell lines offer superior specificity, reliable reproducibility, and ease of handling in laboratory settings. Their unique genetic modification ensures that researchers have a robust tool for analyzing the impact of targeted gene disruptions without the confounding factors present in conventional systems.
For researchers and clinicians, the value of LLGL1 Gene Knockout Cell Lines extends beyond mere experimentation; they represent an opportunity to deepen our understanding of gene function in health and disease. By employing these advanced biological models, users can generate data that not only aids in elucidating fundamental biological principles but also drives novel therapeutic discoveries.
Our company specializes in providing cutting-edge biological tools that empower the scientific community to push the boundaries of current knowledge. With expertise in genetic engineering and cell line development, we ensure our products meet the highest standards of quality and innovation, facilitating groundbreaking research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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