Home / LITAF Knockout Cell Lines

LITAF Knockout Cell Lines

Gene: LITAF

Official Full Name: lipopolysaccharide induced TNF factorprovided by HGNC

Gene Summary: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33161 LITAF Knockout cell line (HeLa) Human LITAF 1:3~1:6 Negative Online Inquiry
KO33162 LITAF Knockout cell line (HCT 116) Human LITAF 1:2~1:4 Negative Online Inquiry
KO33163 LITAF Knockout cell line (HEK293) Human LITAF 1:3~1:6 Negative Online Inquiry
KO33164 LITAF Knockout cell line (A549) Human LITAF 1:3~1:4 Negative Online Inquiry

Background

LITAF Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the LITAF (lipopolysaccharide-induced tumor necrosis factor-alpha factor) gene's role in inflammation and immune responses. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, which allows for the precise alteration of the target gene, effectively disabling its function. The elimination of the LITAF gene provides researchers with a unique tool to explore the gene's contributions to various biological processes, including cytokine production, apoptosis, and cellular stress responses.

The primary function of these knockout cell lines lies in their ability to serve as a versatile platform for examining the downstream effects of LITAF deprivation on cellular behavior. By using these cell lines, scientists can assess how the absence of LITAF influences signaling pathways relevant to inflammation and immune regulation. Such studies are crucial in understanding diseases characterized by dysregulated immune responses, such as autoimmune disorders and chronic inflammatory conditions.

From a scientific perspective, LITAF Gene Knockout Cell Lines enhance the ability to develop targeted therapies and diagnostic tools that could revolutionize treatment strategies. In clinical settings, understanding LITAF's role may lead to novel interventions that alleviate the burden of inflammation-related diseases, positioning these cell lines as essential resources in translational and preclinical research.

Compared to conventional cell lines that express the LITAF gene, these knockout models offer clearer insights into its biological significance by eliminating variability and enabling more focused experimentation. The precise gene editing created by our LITAF knockout lines establishes a reproducible framework for researchers, allowing them to achieve consistent results across their studies.

For researchers and clinicians alike, the value of LITAF Gene Knockout Cell Lines is undeniable. They not only provide a deeper understanding of immune mechanisms but also help pave the way for groundbreaking therapeutic approaches. Our company is dedicated to delivering high-quality biological products backed by rigorous scientific research, ensuring that our customers have access to the best tools for their innovative work in cellular and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.