Gene: LIMS1
Official Full Name: LIM zinc finger domain containing 1provided by HGNC
Gene Summary: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36821 | LIMS1 Knockout cell line (HeLa) | Human | LIMS1 | 1:3~1:6 | Negative | Online Inquiry |
KO36822 | LIMS1 Knockout cell line (HCT 116) | Human | LIMS1 | 1:2~1:4 | Negative | Online Inquiry |
KO36823 | LIMS1 Knockout cell line (HEK293) | Human | LIMS1 | 1:3~1:6 | Negative | Online Inquiry |
KO36824 | LIMS1 Knockout cell line (A549) | Human | LIMS1 | 1:3~1:4 | Negative | Online Inquiry |
LIMS1 Gene Knockout Cell Lines are specially engineered cellular models in which the LIMS1 gene has been permanently disrupted to facilitate research into its functional role in cellular processes. Through targeted gene disruption techniques, such as CRISPR-Cas9 or traditional homologous recombination, these knockout cell lines provide a vital tool to dissect the biological functions of LIMS1, which is implicated in various cellular pathways, including signaling, adhesion, and response to environmental stressors.
The primary mechanism of action involves the loss of LIMS1 protein expression, enabling researchers to observe the resultant phenotypic changes. By studying these alterations, scientists can elucidate LIMS1’s involvement in specific biological processes and disease mechanisms, particularly in contexts such as cancer, where its expression may correlate with tumor progression or metastasis. These cell lines serve as invaluable models for high-throughput drug screening, pathological studies, and the development of novel therapeutic interventions.
In comparison to conventional experimental methods, LIMS1 Gene Knockout Cell Lines stand out due to their specificity and reproducibility. Traditional methods like gene knockdown often lead to only temporary effects and do not provide the stability required for long-term studies. In contrast, our knockout models offer a stable and knockdown-free alternative that researchers can rely on for consistent results over extended periods.
For researchers and clinicians seeking to explore new dimensions of gene function and disease pathology, LIMS1 Gene Knockout Cell Lines provide a robust platform that enhances the accuracy of experimental outcomes. Their precise targeting and unequivocal loss-of-function make them indispensable resources in the context of genetic studies and therapeutic innovation.
Our company brings over a decade of expertise in developing high-quality biological products that support cutting-edge research and improve the success rate of scientific endeavors. With a commitment to excellence, we strive to offer advanced solutions like LIMS1 Gene Knockout Cell Lines that empower researchers to achieve their scientific goals.
Please note that all services are for research use only. Not intended for any clinical use.
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