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LHPP Knockout Cell Lines

Gene: LHPP

Official Full Name: phospholysine phosphohistidine inorganic pyrophosphate phosphataseprovided by HGNC

Gene Summary: Enables inorganic diphosphate phosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16556 LHPP Knockout cell line (HeLa) Human LHPP 1:3~1:6 Negative Online Inquiry
KO16557 LHPP Knockout cell line (HCT 116) Human LHPP 1:2~1:4 Negative Online Inquiry
KO16558 LHPP Knockout cell line (HEK293) Human LHPP 1:3~1:6 Negative Online Inquiry
KO16559 LHPP Knockout cell line (A549) Human LHPP 1:3~1:4 Negative Online Inquiry

Background

LHPP Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the lysine-histidine transporter HPP (PHF6), a gene implicated in various physiological processes and diseases. Utilizing CRISPR-Cas9 genome editing technology, these knockout cell lines effectively disable the LHPP gene, allowing researchers to observe the resulting phenotypic changes and elucidate the gene's biological functions. This advanced method offers precise genetic modifications that ensure a reliable platform for experimental investigations.

The key mechanism of LHPP Gene Knockout Cell Lines involves the targeted disruption of the LHPP gene, ultimately leading to the loss of its protein product. This disruption enables researchers to study the physiological and biochemical pathways influenced by LHPP, including its role in cellular metabolism and its implications in cancer and neurodegenerative disorders. By providing a tailored environment lacking the LHPP gene expression, these cell lines serve as essential tools in dissecting disease mechanisms and drug responses.

Scientifically, the use of LHPP Gene Knockout Cell Lines is paramount in the realm of molecular biology and therapeutic research. They provide a non-invasive model system to analyze gene function, allowing for high-throughput screening of potential therapeutic agents and the evaluation of gene-targeted therapies in a controlled setting. As such, these tools are invaluable for researchers seeking to explore gene-disease correlations and identify novel biomarkers or therapeutic targets.

The distinct advantage of LHPP Gene Knockout Cell Lines lies in their specificity and reliability compared to other genetic manipulation methods. Unlike conventional transfection methods that may result in heterogeneous populations, these knockout lines provide a homogeneous genetic background, enhancing reproducibility and accuracy in research. Furthermore, the availability of a product that is pre-validated for specific LHPP gene targeting saves time and resources, allowing researchers and clinicians to focus on their core scientific inquiries.

In conclusion, LHPP Gene Knockout Cell Lines represent a significant advancement in genetic research tools, catering to researchers, clinicians, and pharmaceutical companies alike. With our company’s commitment to providing high-quality biological products and cutting-edge technologies, we ensure that our customers have access to the most reliable and innovative solutions for their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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