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KTN1 Knockout Cell Lines

Gene: KTN1

Official Full Name: kinectin 1provided by HGNC

Gene Summary: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36860 KTN1 Knockout cell line (HeLa) Human KTN1 1:3~1:6 Negative Online Inquiry
KO36861 KTN1 Knockout cell line (HCT 116) Human KTN1 1:2~1:4 Negative Online Inquiry
KO36862 KTN1 Knockout cell line (HEK293) Human KTN1 1:3~1:6 Negative Online Inquiry
KO36863 KTN1 Knockout cell line (A549) Human KTN1 1:3~1:4 Negative Online Inquiry

Background

KTN1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the in-depth study of the KTN1 gene's role in various biological processes. The KTN1 gene encodes a protein that is implicated in cellular signaling pathways and cytoskeletal regulation. These knockout cell lines employ CRISPR-Cas9 technology to specifically disrupt the KTN1 gene, leading to a functional loss of its protein product. This targeted gene knockout allows researchers to investigate the resulting phenotypic changes, elucidating the molecular mechanisms underlying KTN1’s involvement in cellular functions.

The primary mechanism of action involves the precise editing of the genomic DNA, which results in the absence of KTN1 protein expression. This absence allows for the exploration of alternative signaling pathways that may compensate for the loss, and the potential identification of novel targets for therapeutic intervention. The analysis of KTN1 knockout cells can reveal insights into processes such as cell migration, proliferation, and apoptosis, making these cell lines invaluable for basic research, drug development, and disease modeling.

Scientifically, the KTN1 Gene Knockout Cell Lines hold significant importance in both academic and clinical research, especially in studies focused on cancers and neurodegenerative diseases where KTN1's regulatory capabilities may be disrupted. These models can accelerate discoveries by providing a clear comparison to wild-type cells, enhancing the understanding of the associated disease mechanisms.

Unlike alternative gene knockout strategies, such as insertional mutagenesis or RNAi-mediated knockdown, KTN1 Gene Knockout Cell Lines offer complete and permanent loss of function, providing a more definitive tool for validating experimental outcomes. This ensures higher specificity and reliability in experimental results, thus simplifying data interpretation.

For researchers and clinicians, these cell lines are essential resources that promise enhanced insights into KTN1’s biological roles, making them invaluable in advancing therapeutic strategies and understanding complex disease states. Our company, with its extensive expertise in creating and providing high-quality biological products, is committed to empowering your research with precision-engineered tools like the KTN1 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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