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KNSTRN Knockout Cell Lines

Gene: KNSTRN

Official Full Name: kinetochore localized astrin (SPAG5) binding proteinprovided by HGNC

Gene Summary: Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03307 KNSTRN Knockout cell line (HeLa) Human KNSTRN 1:3~1:6 Negative Online Inquiry
KO03308 KNSTRN Knockout cell line (HCT 116) Human KNSTRN 1:2~1:4 Negative Online Inquiry
KO03309 KNSTRN Knockout cell line (HEK293) Human KNSTRN 1:3~1:6 Negative Online Inquiry
KO03310 KNSTRN Knockout cell line (A549) Human KNSTRN 1:3~1:4 Negative Online Inquiry

Background

KNSTRN Gene Knockout Cell Lines are genetically engineered cellular models that have had the KNSTRN gene specifically disrupted or "knocked out." This process enables researchers to study the cellular and molecular functions of KNSTRN, an essential protein involved in various cellular processes, including cell cycle regulation, spindle assembly, and chromosomal organization. By utilizing these knockout cell lines, scientists can investigate the biological consequences of the absence of KNSTRN, elucidating its role in tumorigenesis, cell proliferation, and differentiation.

These cell lines function through precise genetic editing techniques, such as CRISPR-Cas9, which cause targeted deletions in the KNSTRN gene. As a result, researchers can observe phenotypic changes and alterations in signaling pathways, providing critical insights into cancer biology and potential therapeutic targets. The applications of KNSTRN Gene Knockout Cell Lines are vast, spanning basic research to translational science, thereby enabling studies that could lead to novel treatment strategies for diseases related to improper cell cycle regulation, including diverse cancers.

One of the distinguishing advantages of KNSTRN Gene Knockout Cell Lines is their unparalleled specificity and reliability. Unlike traditional temporary gene knockdown methods, our knockout lines provide a permanent reduction of target expression, making experimental results more robust and reproducible. Furthermore, these cell lines are rigorously validated, ensuring that users receive consistent and high-quality samples that enhance experimental fidelity.

The value of KNSTRN Gene Knockout Cell Lines lies in their ability to accelerate research findings and foster groundbreaking discoveries. By utilizing these advanced models, researchers and clinicians can explore the fundamental roles of KNSTRN in disease mechanisms, facilitating the development of innovative therapeutic approaches. Our company's dedication to excellence in genetic engineering and cell-based products empowers scientists with the tools necessary for impactful research. We are committed to providing high-quality biological products that support the ongoing quest for knowledge in genetics and cell biology.

Please note that all services are for research use only. Not intended for any clinical use.

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