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KMT2C Knockout Cell Lines

Gene: Kmt2c

Official Full Name: lysine (K)-specific methyltransferase 2Cprovided by MGI

Gene Summary: Enables histone H3K4 methyltransferase activity. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of fibroblast proliferation; and single fertilization. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Human ortholog(s) of this gene implicated in Kleefstra syndrome 2; carcinoma (multiple); and stomach cancer. Orthologous to human KMT2C (lysine methyltransferase 2C). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02126 KMT2C Knockout cell line (HeLa) Human KMT2C 1:3~1:6 Negative Online Inquiry
KO02127 KMT2C Knockout cell line (HCT 116) Human KMT2C 1:2~1:4 Negative Online Inquiry
KO02128 KMT2C Knockout cell line (HEK293) Human KMT2C 1:3~1:6 Negative Online Inquiry
KO02129 KMT2C Knockout cell line (A549) Human KMT2C 1:3~1:4 Negative Online Inquiry

Background

Kmt2c Gene Knockout Cell Lines are specially engineered cellular models that have undergone targeted gene editing to deactivate the Kmt2c gene, known for its role in chromatin modification and gene regulation. This product allows researchers to investigate the functional consequences of Kmt2c loss, shedding light on its involvement in various biological processes, including cell differentiation, proliferation, and epigenetic regulation.

The primary mechanism by which Kmt2c knockout alters cellular behavior involves the disruption of histone methylation patterns, which can significantly impact gene expression profiles. This alteration can lead to remarkable changes in cellular phenotype, making these cell lines invaluable for dissecting the gene's role in disease models and therapeutic development. By utilizing these knockout cell lines, researchers can effectively study the pathways influenced by Kmt2c and assess how its loss contributes to pathologies such as cancer, neurodegeneration, and other disorders.

The scientific significance of Kmt2c Gene Knockout Cell Lines is underscored by their utility in both basic research and clinical applications. They not only serve as a powerful tool for functional genomics but also enhance drug discovery efforts by providing a platform for screening compounds that may target altered cellular pathways due to Kmt2c disruption. Compared to traditional models or non-specific gene silencing methods, these knockout cell lines offer greater specificity, reproducibility, and the ability to establish clearer cause-and-effect relationships related to gene function.

For researchers and clinicians keen on advancing their understanding of gene regulation and implications in health and disease, Kmt2c Gene Knockout Cell Lines represent a significant leap forward. They are equipped with robust performance metrics and reproducibility across experiments, ensuring that users can confidently draw conclusions from their findings.

Our company prides itself on a commitment to biological innovation and the continuous development of cutting-edge tools for researchers worldwide. With extensive expertise in gene editing technologies, we provide high-quality cell lines that meet the rigorous demands of modern scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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