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KLHL9 Knockout Cell Lines

Gene: KLHL9

Official Full Name: kelch like family member 9provided by HGNC

Gene Summary: This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21479 KLHL9 Knockout cell line (HeLa) Human KLHL9 1:3~1:6 Negative Online Inquiry
KO21480 KLHL9 Knockout cell line (HCT 116) Human KLHL9 1:2~1:4 Negative Online Inquiry
KO21481 KLHL9 Knockout cell line (HEK293) Human KLHL9 1:3~1:6 Negative Online Inquiry
KO21482 KLHL9 Knockout cell line (A549) Human KLHL9 1:3~1:4 Negative Online Inquiry

Background

KLHL9 Gene Knockout Cell Lines are genetically engineered cellular models that have had the KLHL9 gene selectively disrupted, facilitating in-depth studies of its biological functions and implications in various disease processes. The KLHL9 gene encodes a member of the Kelch-like protein family, which is involved in essential cellular processes, including cell signaling, cytoskeletal organization, and protein degradation pathways. The knockout of KLHL9 enables researchers to elucidate the role of this gene in the context of cellular behavior, development, and disease pathogenesis, particularly in cancer research and neurodegenerative disorders.

The primary mechanism by which these cell lines function is through the complete absence of the KLHL9 protein, thereby allowing investigators to observe both loss-of-function effects and the downstream consequences of its absence. This provides a unique platform for studying compensatory mechanisms and alternative pathways activated in response to KLHL9 depletion. By utilizing these knockout cell lines, researchers can generate more accurate models that reflect the functionality of KLHL9 in vivo, leading to insights into its involvement in complex biological systems.

The scientific importance of KLHL9 Gene Knockout Cell Lines resides in their ability to serve as critical tools for drug discovery and therapeutic development. They can be used to screen potential compounds for efficacy against diseases involving dysregulation of KLHL9 or its downstream targets. Moreover, these cell lines offer the potential for biomarker identification and validation in clinical settings, enhancing personalized medicine approaches.

Compared to traditional cellular models, KLHL9 knockout cell lines provide a specific advantage by allowing for targeted investigations into the consequences of gene deletion without the confounding effects of genetic variability. This specificity results in more reproducible and interpretable results, making them invaluable resources for researchers striving to achieve clarity in their studies.

For researchers, clinicians, and biotechnologists, KLHL9 Gene Knockout Cell Lines stand as a pivotal resource in advancing the understanding of gene function and disease correlations. Our commitment to providing premium biological products stems from years of expertise in genetic engineering and cell line development, ensuring that our clients receive high-quality tools that facilitate cutting-edge research and innovation in biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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