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KLHL4 Knockout Cell Lines

Gene: KLHL4

Official Full Name: kelch like family member 4provided by HGNC

Gene Summary: This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20221 KLHL4 Knockout cell line (HeLa) Human KLHL4 1:3~1:6 Negative Online Inquiry
KO20222 KLHL4 Knockout cell line (A549) Human KLHL4 1:3~1:4 Negative Online Inquiry

Background

KLHL4 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional impact of the KLHL4 gene, a critical component involved in various biological processes, including protein degradation and cellular homeostasis. By employing CRISPR-Cas9 genome editing technology, these cell lines provide a precise knockout of the KLHL4 gene, enabling researchers to investigate the consequences of its loss in both physiological and pathological contexts.

The primary function of KLHL4 is to regulate the ubiquitin-proteasome system, a key mechanism for protein turnover and quality control within cells. Alterations in KLHL4 expression have been associated with several disease states, including cancer and neurodegenerative disorders, making it vital for understanding cellular mechanisms underlying these conditions. Researchers can utilize these knockout lines to explore KLHL4's role in protein interactions and signaling pathways, providing insights that may lead to novel therapeutic strategies.

In terms of scientific importance, KLHL4 Gene Knockout Cell Lines can be applied in various research disciplines, such as cancer biology, cellular metabolism, and developmental biology. Their use in drug discovery processes can expedite the identification of molecular targets and biomarker validation. Additionally, the ability to replicate pathological features in vitro allows for a better understanding of disease mechanisms, providing a solid foundation for translational research.

The unique selling points of KLHL4 Gene Knockout Cell Lines include their high reproducibility, customizable backgrounds, and the specificity of the knockout, which surpasses many traditional methods that rely on RNA interference. This specificity allows for cleaner biological interpretation, a crucial advantage when studying the nuanced roles of KLHL4 in complex cellular systems.

For researchers and clinicians, the value of KLHL4 Knockout Cell Lines lies in their robustness and the rich data they generate, which can directly inform future experiments and clinical applications. By using these models, users can significantly advance their understanding of protein functions and related diseases, ultimately leading to improved strategies to tackle health-related challenges.

At [Your Company Name], we pride ourselves on delivering high-quality biological products backed by cutting-edge research. Our expertise in gene editing technologies and commitment to advancing scientific discovery ensure that our KLHL4 Gene Knockout Cell Lines are an invaluable resource for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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