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KLHL22 Knockout Cell Lines

Gene: KLHL22

Official Full Name: kelch like family member 22provided by HGNC

Gene Summary: Enables 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cellular response to L-leucine; mitotic spindle assembly checkpoint signaling; and negative regulation of metabolic process. Located in several cellular components, including intercellular bridge; lysosome; and microtubule cytoskeleton. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24579 KLHL22 Knockout cell line (HeLa) Human KLHL22 1:3~1:6 Negative Online Inquiry
KO24580 KLHL22 Knockout cell line (HCT 116) Human KLHL22 1:2~1:4 Negative Online Inquiry
KO24581 KLHL22 Knockout cell line (HEK293) Human KLHL22 1:3~1:6 Negative Online Inquiry
KO24582 KLHL22 Knockout cell line (A549) Human KLHL22 1:3~1:4 Negative Online Inquiry

Background

KLHL22 Gene Knockout Cell Lines represent a cutting-edge tool for researchers in the fields of molecular biology and genetics. These specifically engineered mammalian cell lines have been modified to lack the KLHL22 gene, which encodes a protein that plays pivotal roles in cellular processes such as protein degradation and gene regulation. By employing CRISPR-Cas9 technology, these knockout cell lines provide a precise and effective model for studying the biological implications of KLHL22 in various physiological and pathological contexts.

The key function of the KLHL22 knockout cell lines lies in their ability to elucidate the gene's role in mechanisms including cellular signaling pathways, immune responses, and various disease states. By enabling researchers to observe the phenotypic and functional consequences of genetic ablation, these cell lines allow for the investigation of KLHL22's contribution to disorders such as cancer and autoimmune diseases. The absence of KLHL22 facilitates in-depth studies on protein interactions and cellular responses that could lead to new therapeutic targets.

From a scientific standpoint, the availability of KLHL22 knockout cell lines has significant implications for both basic and applied research. Their applications range from understanding fundamental cellular biology to the development of innovative treatments, making them invaluable in both academic and clinical settings. Compared to traditional knockout methodologies, our KLHL22 cell lines offer greater efficiency, reproducibility, and reduced time in generating stable models, addressing common limitations associated with older techniques.

What sets these knockout cell lines apart is their proven reliability and robustness in experimental setups, making them a preferred choice among researchers. Additionally, these cell lines are routinely characterized for key features, ensuring high-quality performance with minimal variability. Researchers and clinicians can benefit from this product by obtaining consistent and reproducible data critical for advancing scientific knowledge and therapeutic development.

At [Your Company Name], we pride ourselves on our expertise in biotechnology and our commitment to providing high-quality biological research products. The KLHL22 gene knockout cell lines are a testament to our dedication to supporting the scientific community with state-of-the-art tools that drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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