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KLF5 Knockout Cell Lines

Gene: KLF5

Official Full Name: KLF transcription factor 5provided by HGNC

Gene Summary: This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02575 KLF5 Knockout cell line (HeLa) Human KLF5 1:3~1:6 Negative Online Inquiry
KO02576 KLF5 Knockout cell line (HCT 116) Human KLF5 1:2~1:4 Negative Online Inquiry
KO02577 KLF5 Knockout cell line (HEK293) Human KLF5 1:3~1:6 Negative Online Inquiry
KO02578 KLF5 Knockout cell line (A549) Human KLF5 1:3~1:4 Negative Online Inquiry

Background

KLF5 Gene Knockout Cell Lines are advanced biological tools developed to study the functional implications of the KLF5 gene in various cellular processes. These specially engineered cell lines exhibit a complete knockout of the KLF5 gene, allowing researchers to investigate the gene's role in regulating cell differentiation, proliferation, and apoptosis without the confounding influence of its expression.

The knockout mechanism is achieved using CRISPR-Cas9 technology, which ensures precise editing of the genome, leading to the disruption of the KLF5 coding sequence. By providing a platform devoid of KLF5 activity, these cell lines facilitate extensive studies that can elucidate the downstream effects of KLF5 on signaling pathways and gene expression profiles, helping to establish its role in physiological and pathological contexts such as cancer, cardiovascular diseases, and metabolic disorders.

The scientific importance of KLF5 Gene Knockout Cell Lines is underscored by their applications in research settings, where they serve as pivotal models for drug development and biological investigation. Researchers can leverage these cell lines to explore therapeutic targets and develop treatment strategies for diseases characterized by aberrant KLF5 activity.

Compared to alternative approaches, such as pharmacological inhibition or overexpression studies, the KLF5 Gene Knockout Cell Lines offer a clean and robust solution to delineate gene function without the complexities introduced by partial inhibition or compensatory mechanisms of other pathways. This specificity enhances the accuracy of experimental outcomes and allows for more reproducible results.

For researchers and clinicians seeking a deeper understanding of gene function in complex biological systems, the KLF5 Gene Knockout Cell Lines represent a valuable asset. Their potential to unlock insights into fundamental biological processes and disease mechanisms makes them a crucial tool in the arsenal of modern molecular biology.

Our company, with its commitment to advancing research and innovation in the life sciences, specializes in creating high-quality genetic models that empower scientists in their pursuit of knowledge and therapeutic advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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