KIR2DL5B Knockout Cell Lines

Gene: KIR2DL5B

Official Full Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5Bprovided by HGNC

Gene Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO16706	KIR2DL5B Knockout cell line (HeLa)	Human	KIR2DL5B	1:3~1:6	Negative	Online Inquiry
KO16707	KIR2DL5B Knockout cell line (HCT 116)	Human	KIR2DL5B	1:2~1:4	Negative	Online Inquiry
KO16708	KIR2DL5B Knockout cell line (HEK293)	Human	KIR2DL5B	1:3~1:6	Negative	Online Inquiry
KO16709	KIR2DL5B Knockout cell line (A549)	Human	KIR2DL5B	1:3~1:4	Negative	Online Inquiry

Background

KIR2DL5B Gene Knockout Cell Lines are tailored biological tools designed to facilitate the study of the KIR2DL5B gene and its implications in immune response regulation. These genetically modified cell lines have undergone a precise knockout of the KIR2DL5B gene, resulting in the absence of its protein product. This knockout enables researchers to investigate the downstream effects and cellular pathways that are influenced by KIR2DL5B activation or inhibition.

The primary function of KIR2DL5B, an inhibitory receptor found on natural killer (NK) cells, involves its interaction with specific ligands expressed on target cells, promoting immune tolerance and modulating the activity of NK cells. By utilizing these knockout cell lines, researchers can elucidate the role of KIR2DL5B in tumor immunity, autoimmunity, and infectious disease. This understanding is critical for advancing therapeutic strategies that leverage NK cell activity in both research and clinical contexts.

The scientific importance of KIR2DL5B knockout cell lines lies in their application in basic research, drug discovery, and therapeutic development. They serve as a valuable platform for screening potential immunotherapeutic agents, understanding NK cell behaviors, and harnessing the immune system against malignancies. Compared to traditional cell lines, these knockout models provide a more relevant biological context, allowing for the exploration of specific mechanisms without the confounding effects of KIR2DL5B expression.

What sets these knockout cell lines apart is their rigorous validation and optimization for experimental reproducibility, combined with ease of use across diverse laboratory settings. Furthermore, they offer researchers a unique opportunity to generate data that can lead to breakthroughs in immunology research and potential clinical applications.

For researchers and clinicians seeking to enhance their understanding of immune mechanisms and improve therapeutic outcomes, KIR2DL5B Gene Knockout Cell Lines represent an indispensable tool. Our company prides itself on delivering high-quality biological products backed by extensive expertise in genetic engineering and cell biology, ensuring that you have access to innovative solutions for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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