Gene: KIF1B
Official Full Name: kinesin family member 1Bprovided by HGNC
Gene Summary: Enables plus-end-directed microtubule motor activity. Involved in apoptotic process involved in development and mitochondrion transport along microtubule. Is active in mitochondrion. Implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29872 | KIF1B Knockout cell line (HeLa) | Human | KIF1B | 1:3~1:6 | Negative | Online Inquiry |
KO29873 | KIF1B Knockout cell line (HCT 116) | Human | KIF1B | 1:2~1:4 | Negative | Online Inquiry |
KO29874 | KIF1B Knockout cell line (HEK293) | Human | KIF1B | 1:3~1:6 | Negative | Online Inquiry |
KO29875 | KIF1B Knockout cell line (A549) | Human | KIF1B | 1:3~1:4 | Negative | Online Inquiry |
KIF1B Gene Knockout Cell Lines are genetically engineered cell lines that have had the KIF1B gene specifically disrupted, providing invaluable tools for the study of gene function and regulation. KIF1B encodes a motor protein that is essential for the transport of organelles and signaling molecules along microtubules in neurons and other cell types. By employing CRISPR/Cas9 technology, the resultant knockout cell lines exhibit a complete loss of KIF1B expression, enabling researchers to investigate the cellular ramifications of KIF1B deficiency in various biological contexts.
The primary functions of these knockout cell lines manifest through their ability to recapitulate phenotypic changes associated with KIF1B loss. Researchers can explore altered intracellular transport dynamics, neuronal signaling pathways, and related cellular processes that may contribute to neurological disorders, making these cell lines particularly important for studies aiming to understand neurodevelopment and neuropathogenesis. The knockout model presents a valuable avenue for therapeutic investigation, potentially leading to targeted treatments for diseases where KIF1B is implicated.
Compared to traditional methods of gene silencing, such as RNA interference, KIF1B Gene Knockout Cell Lines present several advantages. The CRISPR-mediated knockout leads to a permanent and heritable disruption of the KIF1B gene, offering more stable and reliable experimental outcomes. Moreover, these cell lines can be utilized in a wide array of mammalian systems, which enhances their applicability in translational research.
The unique selling points of our KIF1B Gene Knockout Cell Lines lie not only in their specificity and robustness but also in their ability to provide a clear and unambiguous model for studying KIF1B function. Researchers and clinicians alike will find these tools valuable for elucidating disease mechanisms and developing novel therapeutic strategies.
Leveraging years of expertise in genetic engineering and cell line development, our company is dedicated to providing high-quality biological products that empower scientific inquiry and advancement. With rigorous quality control and comprehensive support, we remain committed to facilitating your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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