Gene: KIF13A
Official Full Name: kinesin family member 13Aprovided by HGNC
Gene Summary: This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16735 | KIF13A Knockout cell line (HeLa) | Human | KIF13A | 1:3~1:6 | Negative | Online Inquiry |
KO16736 | KIF13A Knockout cell line (HCT 116) | Human | KIF13A | 1:2~1:4 | Negative | Online Inquiry |
KO16737 | KIF13A Knockout cell line (HEK293) | Human | KIF13A | 1:3~1:6 | Negative | Online Inquiry |
KO16738 | KIF13A Knockout cell line (A549) | Human | KIF13A | 1:3~1:4 | Negative | Online Inquiry |
KIF13A Gene Knockout Cell Lines are specialized cellular models designed to investigate the function of the KIF13A gene, which encodes a motor protein involved in intracellular transport processes. By utilizing CRISPR-Cas9 technology, these cell lines have been engineered to completely disrupt the expression of KIF13A, facilitating the study of its role in various biological pathways and disease mechanisms.
The primary function of KIF13A involves its participation in the transport of cellular cargo along microtubules, which is crucial for maintaining cellular homeostasis and enabling proper signaling. The knockout of this gene provides researchers with a powerful tool to elucidate its contribution to cellular processes such as cell division, migration, and the transport of organelles and vesicles. Mechanistically, loss of KIF13A can modulate downstream pathways and affect overall cellular architecture, making these knockout cell lines invaluable for probing fundamental biological questions.
Scientifically, KIF13A Gene Knockout Cell Lines hold immense importance in both research and clinical applications. They can be instrumental in exploring cancer biology, neurodegenerative diseases, and various other conditions where intracellular transport plays a pivotal role. By utilizing these cell lines, researchers can develop targeted therapeutics and improve our understanding of disease mechanisms, ultimately leading to advancements in clinical practices.
Compared to traditional cell lines, KIF13A knockout models offer specific advantages such as reproducibility and precision, allowing for more accurate modeling of KIF13A-related diseases. Moreover, their ease of use can significantly reduce experimental variability and enhance the reliability of data, making them a superior choice for researchers focused on the intricacies of cellular function.
In summary, KIF13A Gene Knockout Cell Lines are essential tools for researchers and clinicians eager to explore the complexities of therapeutic targets related to intracellular transport. Our company specializes in providing high-quality biological products, and our expertise ensures that these cell lines meet rigorous testing standards, enabling cutting-edge research in molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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