Gene: KIDINS220
Official Full Name: kinase D interacting substrate 220provided by HGNC
Gene Summary: This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09518 | KIDINS220 Knockout cell line (HeLa) | Human | KIDINS220 | 1:3~1:6 | Negative | Online Inquiry |
KO09519 | KIDINS220 Knockout cell line (HCT 116) | Human | KIDINS220 | 1:2~1:4 | Negative | Online Inquiry |
KO09520 | KIDINS220 Knockout cell line (HEK293) | Human | KIDINS220 | 1:3~1:6 | Negative | Online Inquiry |
KO09521 | KIDINS220 Knockout cell line (A549) | Human | KIDINS220 | 1:3~1:4 | Negative | Online Inquiry |
KIDINS220 Gene Knockout Cell Lines represent an advanced tool in molecular biology that facilitates the study of the KIDINS220 gene, known for its involvement in neurodevelopment and cellular signaling pathways. These cell lines are meticulously engineered to lack the expression of the KIDINS220 gene, allowing researchers to elucidate its biological functions and understand its role in various physiological and pathological processes.
The primary mechanism of these knockout cell lines is the targeted deletion of the KIDINS220 gene through CRISPR/Cas9 technology, leading to a complete absence of the KIDINS220 protein. This precise gene editing ensures that any observed phenotypic changes can directly be attributed to the loss of KIDINS220, thereby providing clarity in functional studies. Researchers can utilize these cell lines for a multitude of applications, including drug screening, signal transduction studies, and the investigation of developmental biology and cancer mechanisms.
The scientific importance of KIDINS220 knockout cell lines is underscored by their potential to uncover insights into neurodevelopmental disorders and cancer biology, where aberrant signaling pathways are frequently implicated. This product offers significant advantages over traditional methods, such as the use of siRNA or shRNA, as it enables stable and complete gene knockout without the transient effects associated with knockdown techniques. Furthermore, these cell lines can be used repeatedly, providing a consistent and reliable model for experimental validation.
For researchers and clinicians alike, KIDINS220 Gene Knockout Cell Lines present an invaluable resource that enhances the pursuit of innovative therapeutic strategies and a deeper understanding of complex biological systems. Our company is dedicated to providing high-quality, tailored solutions for research, and with our expertise in gene editing technologies, we ensure that our products meet the rigorous standards of scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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