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KCTD17 Knockout Cell Lines

Gene: KCTD17

Official Full Name: potassium channel tetramerization domain containing 17provided by HGNC

Gene Summary: This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16800 KCTD17 Knockout cell line (HeLa) Human KCTD17 1:3~1:6 Negative Online Inquiry
KO16801 KCTD17 Knockout cell line (HCT 116) Human KCTD17 1:2~1:4 Negative Online Inquiry
KO16802 KCTD17 Knockout cell line (HEK293) Human KCTD17 1:3~1:6 Negative Online Inquiry
KO16803 KCTD17 Knockout cell line (A549) Human KCTD17 1:3~1:4 Negative Online Inquiry

Background

KCTD17 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the comprehensive study of the KCTD17 gene's functions and its role in both physiological and pathological conditions. These genetically modified cell lines have undergone traditional CRISPR/Cas9 gene-editing technology to create specific deletions of the KCTD17 gene, allowing researchers to investigate the gene's impact on cellular processes without the influence of its expression.

The primary mechanism of these knockout cell lines revolves around the ablation of gene function, providing a controlled environment to assess resulting phenotypic changes. By comparing the KCTD17 knockout cells with wild-type counterparts, researchers can elucidate the gene’s contribution to signaling pathways, cellular proliferation, differentiation, and apoptosis. This provides essential insights not only for understanding basic cellular biology but also for investigating disease mechanisms where KCTD17 may play a pivotal role, such as in neurodegenerative disorders or cancers.

In terms of scientific importance, KCTD17 has been implicated in several biological processes, making these cell lines invaluable tools in both research and therapeutic development settings. They offer a streamlined approach for drug discovery, functional genomics and the identification of genetic interactions, thus accelerating the pace of scientific inquiry.

What distinguishes our KCTD17 Gene Knockout Cell Lines is their high specificity and reliability, alongside robust validation to ensure effective gene editing. Unlike some alternative methods that may result in off-target effects, our cell lines are crafted to minimize such discrepancies, providing researchers with invaluable, consistent data.

Furthermore, our product is backed by our extensive expertise in genomic engineering and cell line development, ensuring that we provide not just a product but a partnership in advancing scientific research. The KCTD17 Gene Knockout Cell Lines offer a unique opportunity to enhance your research capabilities, empower your discoveries, and contribute significantly to the burgeoning field of genetic research.

Please note that all services are for research use only. Not intended for any clinical use.

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