Gene: KCNS3
Official Full Name: potassium voltage-gated channel modifier subfamily S member 3provided by HGNC
Gene Summary: Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36978 | KCNS3 Knockout cell line (HCT 116) | Human | KCNS3 | 1:2~1:4 | Negative | Online Inquiry |
KO36979 | KCNS3 Knockout cell line (HEK293) | Human | KCNS3 | 1:3~1:6 | Negative | Online Inquiry |
KO36980 | KCNS3 Knockout cell line (A549) | Human | KCNS3 | 1:3~1:4 | Negative | Online Inquiry |
KCNS3 Gene Knockout Cell Lines are highly specialized biological products designed to facilitate the in-depth study of the KCNS3 gene, which encodes a voltage-gated potassium channel, specifically the K_v9.3 subunit. These cell lines have undergone precise genomic editing to create a complete knockout of the KCNS3 gene, providing researchers with powerful tools to investigate the gene's functional role in various cellular processes and its potential implications in neurophysiological disorders.
The key function of KCNS3 Gene Knockout Cell Lines lies in their ability to elucidate the cellular and molecular mechanisms governed by the KCNS3 protein. By removing the expression of this gene, scientists can explore the effects on neuronal excitability, neurotransmitter release, and ion homeostasis, ultimately leading to a better understanding of conditions such as epilepsy, pain, and cognitive dysfunction. These cell lines can serve as a platform for pharmacological studies, allowing for the screening of potential compounds aimed at modulating potassium channel activity.
The scientific importance of KCNS3 Gene Knockout Cell Lines is underscored by their applications in both basic and translational research. Researchers utilize these lines to study potassium channel regulation and signaling pathways, which may lead to novel therapeutic strategies targeting these pathways in various diseases. In clinical settings, insights gained from such studies could pave the way for innovative treatments or diagnostic methodologies for related neurological conditions.
What sets KCNS3 Gene Knockout Cell Lines apart from other conventional cell lines is their customized design tailored specifically for studying the KCNS3 gene, coupled with our commitment to quality assurance and reproducibility. These advantages ensure that researchers receive reliable and consistent results, a crucial factor for advancing their investigations.
For researchers, clinicians, and drug developers, the value of KCNS3 Gene Knockout Cell Lines lies in the potential to unlock new discoveries in ion channel biology and neuropharmacology. By integrating these advanced tools into their research, users can significantly extend the understanding of complex neuronal mechanisms, ultimately fostering the development of innovative therapeutic approaches.
Our company prides itself on its expertise in biological products, leveraging cutting-edge genetic engineering techniques to provide high-quality research tools. We are dedicated to supporting the scientific community in their quest to understand and manipulate biological systems effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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