Gene: KAZN
Official Full Name: kazrin, periplakin interacting proteinprovided by HGNC
Gene Summary: This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29575 | KAZN Knockout cell line (HeLa) | Human | KAZN | 1:3~1:6 | Negative | Online Inquiry |
KO29576 | KAZN Knockout cell line (HCT 116) | Human | KAZN | 1:2~1:4 | Negative | Online Inquiry |
KO29577 | KAZN Knockout cell line (HEK293) | Human | KAZN | 1:3~1:6 | Negative | Online Inquiry |
KO29578 | KAZN Knockout cell line (A549) | Human | KAZN | 1:3~1:4 | Negative | Online Inquiry |
KAZN Gene Knockout Cell Lines are advanced cellular models designed for the targeted disruption of the KAZN gene, enabling researchers to elucidate its functional role in various biological processes. Utilizing CRISPR/Cas9 technology, these cell lines offer precise gene editing capabilities, facilitating accurate studies of gene function, interactions, and related pathways.
The primary mechanism of action involves the introduction of a guide RNA specific to the KAZN gene, which directs the Cas9 endonuclease to create double-strand breaks. This targeted intervention leads to the knockout of the gene, allowing researchers to analyze phenotypic changes, cellular responses, and downstream effects associated with the loss of KAZN function. This level of specificity aids in dissecting gene regulatory networks and evaluating the implications of KAZN in diseases such as cancer and metabolic disorders.
Scientifically, KAZN Gene Knockout Cell Lines serve as invaluable tools in both research and clinical contexts. They provide a foundation for exploring gene function through loss-of-function studies, drug screening, and the validation of therapeutic targets. The implications of findings derived from these cell lines can significantly enhance our understanding of gene-disease relationships and inform future therapeutic strategies.
What sets KAZN Gene Knockout Cell Lines apart from alternative products on the market is their reliability and ease of use. They are developed using highly validated and reproducible protocols, ensuring consistent results across experiments. Additionally, our comprehensive support, including detailed technical information and optimization resources, empowers researchers to maximize the utility of these cell lines in their work.
In conclusion, KAZN Gene Knockout Cell Lines not only advance scientific inquiry into the KAZN gene but also represent a commitment to quality and innovation. Our company specializes in delivering top-tier biological products, ensuring that researchers and clinicians have access to the best tools for their groundbreaking studies. Choose KAZN for superior experimental outcomes and meaningful contributions to the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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