Home / IVD Knockout Cell Lines

IVD Knockout Cell Lines

Gene: IVD

Official Full Name: isovaleryl-CoA dehydrogenaseprovided by HGNC

Gene Summary: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37017 IVD Knockout cell line (HeLa) Human IVD 1:3~1:6 Negative Online Inquiry
KO37018 IVD Knockout cell line (HCT 116) Human IVD 1:2~1:4 Negative Online Inquiry
KO37019 IVD Knockout cell line (HEK293) Human IVD 1:3~1:6 Negative Online Inquiry
KO37020 IVD Knockout cell line (A549) Human IVD 1:3~1:4 Negative Online Inquiry

Background

IVD Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the investigation of gene function, disease mechanisms, and therapeutic applications. Utilizing advanced CRISPR/Cas9 gene-editing technology, these cell lines enable researchers to create targeted gene disruptions, providing a powerful tool for functional genomics studies. By systematically knocking out specific genes, users can observe alterations in cellular behavior, signaling pathways, and phenotypic expressions, thereby elucidating the role of genes in various biological processes.

The key mechanism by which IVD Gene Knockout Cell Lines function involves the introduction of site-specific double-strand breaks in the target gene, followed by the cell's repair process, which can lead to insertions or deletions that disrupt gene function. This allows for a clearer understanding of gene functions in both normal and pathological contexts, making these cell lines invaluable for research in oncology, immunology, and neurobiology.

The scientific importance of these cell lines extends to both basic and applied research settings, enabling the exploration of genetic contributions to diseases, the development of novel therapeutics, and potential advancements in personalized medicine. Furthermore, they serve as essential platforms for drug discovery and toxicity studies, ultimately accelerating the translation of laboratory findings into clinical applications.

One significant advantage of using IVD Gene Knockout Cell Lines over conventional knockout models, such as whole organism models, lies in their time and cost efficiency. Researchers benefit from the ability to conduct experiments in a controlled environment, reduce variability, and achieve faster results when assessing gene function and drug interactions. Additionally, IVD provides comprehensive support and customization options, allowing researchers to choose specific genes based on their unique study needs.

With a commitment to innovation and quality, our company stands at the forefront of developing advanced biological research tools. We leverage our deep expertise in gene editing technology to deliver high-quality, reliable products that empower scientists and clinicians in their quest to uncover new insights in biology and improve patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.