Home / ITPKB Knockout Cell Lines

ITPKB Knockout Cell Lines

Gene: ITPKB

Official Full Name: inositol-trisphosphate 3-kinase Bprovided by HGNC

Gene Summary: The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07947 ITPKB Knockout cell line (HeLa) Human ITPKB 1:3~1:6 Negative Online Inquiry
KO07948 ITPKB Knockout cell line (HCT 116) Human ITPKB 1:2~1:4 Negative Online Inquiry
KO07949 ITPKB Knockout cell line (HEK293) Human ITPKB 1:3~1:6 Negative Online Inquiry
KO07950 ITPKB Knockout cell line (A549) Human ITPKB 1:3~1:4 Negative Online Inquiry

Background

ITPKB Gene Knockout Cell Lines are specialized cellular models designed to study the functional role of the inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) gene, a pivotal player in inositol phosphate signaling pathways. These cell lines have been engineered through CRISPR-Cas9 technology to possess a complete knockout of the ITPKB gene, effectively eliminating its expression and allowing researchers to investigate the downstream effects of its absence on cellular processes.

The primary function of ITPKB involves the regulation of calcium signaling and lipid metabolism, which are crucial for processes such as cell proliferation, differentiation, and apoptosis. By knocking out the ITPKB gene, scientists can gain insight into its specific contributions to these pathways and their implications in various diseases, including cancer and neurodegenerative disorders.

The scientific importance of ITPKB Gene Knockout Cell Lines lies in their utility in both research and clinical settings. They serve as invaluable tools for elucidating signaling mechanisms and can aid in identifying potential therapeutic targets for drug development. For example, understanding the role of ITPKB in cancer can inform on novel strategies for intervention in tumor growth.

Compared to alternative models, our ITPKB Gene Knockout Cell Lines offer distinct advantages, including precise gene editing and greater stability in experimental results compared to transient knockdown approaches. Their validated genetic alterations ensure reliable outcomes for downstream assays, such as drug testing and mechanistic studies.

For researchers and clinicians focused on unraveling complex cellular mechanisms, these cell lines provide an unprecedented opportunity to investigate the intricate roles of inositol phosphate signaling. They facilitate deeper insights into therapeutic avenues for conditions where ITPKB is implicated.

At [Your Company Name], we specialize in advancing bioscience through cutting-edge technology and expert knowledge in genetic editing. Our extensive portfolio includes a range of gene knockout models that empower the scientific community to drive innovation and discovery in cellular and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.