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ITGB4 Knockout Cell Lines

Gene: ITGB4

Official Full Name: integrin subunit beta 4provided by HGNC

Gene Summary: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10283 ITGB4 Knockout cell line (HeLa) Human ITGB4 1:3~1:6 Negative Online Inquiry
KO10284 ITGB4 Knockout cell line (HCT 116) Human ITGB4 1:2~1:4 Negative Online Inquiry
KO10285 ITGB4 Knockout cell line (A549) Human ITGB4 1:3~1:4 Negative Online Inquiry

Background

ITGB4 Gene Knockout Cell Lines are advanced biological tools designed for researchers investigating the role of the integrin beta 4 (ITGB4) gene in various cellular processes. These engineered cell lines are systematically developed using CRISPR-Cas9 technology, which enables precise and targeted disruption of the ITGB4 gene, providing researchers with a powerful platform to study gene function, signaling pathways, and disease mechanisms comprehensively.

The functionality of these knockout cell lines rests on the complete ablation of ITGB4 protein expression, which significantly impacts cellular adhesion, migration, and differentiation processes. This allows researchers to examine how the loss of ITGB4 influences cellular responses in the context of diseases such as cancer, fibrosis, and other integrin-related disorders. By utilizing these cell lines in in vitro experiments, scientists can elucidate critical biological pathways and assess potential therapeutic targets for interventions.

The scientific importance of ITGB4 Gene Knockout Cell Lines cannot be overstated, as they facilitate a greater understanding of integrin-mediated signaling and its implications in pathology. In research and clinical settings, these tools are indispensable for the exploration of targeted therapies and for elucidating the molecular underpinnings of various illnesses.

One of the unique selling points of these cell lines is their high specificity and reliability, providing consistent results across experimental conditions compared to traditional gene knockdown methods. This lack of off-target effects enhances the validity of experimental outcomes, making ITGB4 knockout cell lines a superior choice for rigorous scientific investigation.

For researchers and clinicians alike, the ability to manipulate the ITGB4 pathway opens new avenues for innovative therapies and diagnostics, emphasizing the critical importance of these knockout cell lines in translational research.

Our company is committed to delivering high-quality biological products and pioneering research tools that enrich scientific discovery. With expertise in genetic engineering and cell line development, we ensure our ITGB4 Gene Knockout Cell Lines meet the stringent standards necessary for advancing research excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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