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ITGB1BP1 Knockout Cell Lines

Gene: ITGB1BP1

Official Full Name: integrin subunit beta 1 binding protein 1provided by HGNC

Gene Summary: The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33386 ITGB1BP1 Knockout cell line (HeLa) Human ITGB1BP1 1:3~1:6 Negative Online Inquiry
KO33387 ITGB1BP1 Knockout cell line (HCT 116) Human ITGB1BP1 1:2~1:4 Negative Online Inquiry
KO33388 ITGB1BP1 Knockout cell line (HEK293) Human ITGB1BP1 1:3~1:6 Negative Online Inquiry
KO33389 ITGB1BP1 Knockout cell line (A549) Human ITGB1BP1 1:3~1:4 Negative Online Inquiry

Background

ITGB1BP1 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the integrin beta 1-binding protein 1 (ITGB1BP1) gene. This essential gene encodes a protein implicated in various cellular processes, including cell adhesion, migration, and signaling pathways that are pivotal for maintaining cellular homeostasis. By creating knockout variants of these cell lines, researchers can investigate the specific roles and downstream effects associated with the loss of ITGB1BP1 function.

The primary function of these knockout cell lines lies in their ability to uncouple the gene's influence from other genomic variables, providing a clearer understanding of its biological mechanisms. Researchers can utilize these models to assess altered cellular functions such as proliferation, apoptosis, and interaction with the extracellular matrix, thereby elucidating ITGB1BP1’s involvement in complex physiological and pathological conditions, including cancer and autoimmune disorders.

In terms of scientific importance, ITGB1BP1 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They enable precision studies related to cellular behaviors, therapeutic target validation, and biomarker discovery, assisting in the development of novel therapeutic strategies. Importantly, these cell lines can serve as a foundational tool within drug screening assays and toxicology evaluations.

Compared to alternative models such as wild-type or overexpressing systems, the knockout cell lines provide a unique advantage by allowing conditional investigations free from the confounding effects of intact gene expressions. This specificity enhances the reliability of experimental outcomes and increases the potential for discovering novel insights.

For researchers and clinicians, the value of ITGB1BP1 Gene Knockout Cell Lines cannot be overstated; they provide cutting-edge tools essential for advancing our understanding of cellular mechanisms underlying human diseases. Our company prides itself on delivering high-quality, rigorously validated biological products that empower scientists to push the boundaries of their research. With extensive expertise in gene modification techniques and a commitment to innovation, we offer unparalleled support for pioneering endeavors in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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