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ITGA6 Knockout Cell Lines

Gene: ITGA6

Official Full Name: integrin subunit alpha 6provided by HGNC

Gene Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10299 ITGA6 Knockout cell line (HeLa) Human ITGA6 1:3~1:6 Negative Online Inquiry
KO10300 ITGA6 Knockout cell line (HCT 116) Human ITGA6 1:2~1:4 Negative Online Inquiry
KO10301 ITGA6 Knockout cell line (HEK293) Human ITGA6 1:3~1:6 Negative Online Inquiry
KO10302 ITGA6 Knockout cell line (A549) Human ITGA6 1:3~1:4 Negative Online Inquiry

Background

ITGA6 Gene Knockout Cell Lines are genetically engineered cell lines that have had the ITGA6 gene, which encodes integrin alpha-6, selectively disrupted. Integrin alpha-6 plays a crucial role in cell adhesion, migration, and signaling processes, making these knockout cell lines vital tools for elucidating the biological pathways and mechanisms influenced by this integrin in various cellular contexts.

These cell lines function primarily by lacking the expression of the ITGA6 protein, thereby providing a distinct cellular model to study the signaling pathways typically activated by integrin interactions. Researchers can investigate the resulting phenotypic changes in processes such as cellular proliferation, differentiation, and apoptosis, contributing to a better understanding of how ITGA6 influences normal physiological functions and pathologies like cancer, fibrosis, and autoimmune diseases.

The scientific importance of ITGA6 Gene Knockout Cell Lines extends into both research and clinical applications, particularly in cancer biology, where ITGA6 has been implicated in tumor progression and metastasis. Using these knockout models, scientists can explore novel therapeutic targets and validate the potential efficacy of integrin inhibitors. Furthermore, the availability of rigorous and reproducible experimental systems accelerates the translation of findings from the bench to potential clinical interventions.

One of the unique advantages of our ITGA6 Gene Knockout Cell Lines is the robust validation and high purity of the cell lines provided, ensuring that researchers can obtain reliable data without the background noise often associated with other models. Unlike other alternatives, our cell lines are crafted using precise genome-editing techniques, promising more consistency and greater control over experimental conditions.

For researchers and clinicians aiming to gain actionable insights into the function of integrins, our ITGA6 Gene Knockout Cell Lines present an invaluable resource. With our commitment to advancing scientific knowledge and dedication to quality, our products stand at the forefront of cellular research tools, ensuring researchers receive exceptional support in their quest to unlock new biological discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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