Gene: ITGA4
Official Full Name: integrin subunit alpha 4provided by HGNC
Gene Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10306 | ITGA4 Knockout cell line (HeLa) | Human | ITGA4 | 1:3~1:6 | Negative | Online Inquiry |
KO10307 | ITGA4 Knockout cell line (HEK293) | Human | ITGA4 | 1:3~1:6 | Negative | Online Inquiry |
ITGA4 Gene Knockout Cell Lines are specialized cellular models engineered to silence or disrupt the expression of the ITGA4 gene, which encodes the integrin alpha 4 protein, a critical component in cell adhesion and migration. By utilizing CRISPR/Cas9 or similar gene-editing technologies, these knockout cell lines serve as invaluable tools for researchers investigating the biological pathways in which integrin alpha 4 is involved, including immune response, tissue inflammation, and cancer metastasis.
The primary mechanism behind the functionality of ITGA4 Gene Knockout Cell Lines lies in their ability to elucidate the role of integrin alpha 4 in various cellular processes. By removing or disabling ITGA4 expression, researchers can observe the resulting phenotypic and functional changes in cell behavior, affording them insights into the integrin's contributions to cell attachment, signaling pathways, and interactions with the extracellular matrix. This platform enables a more detailed understanding of complex biological systems and aids in the identification of potential therapeutic targets.
The scientific importance of these cell lines extends into both research and clinical settings, where they can be utilized in drug discovery, development of targeted therapies, and exploration of immune mechanisms in disease contexts. Their applications span numerous fields, including oncology, immunology, and regenerative medicine, positioning them as essential tools for advancing scientific knowledge and therapeutic innovation.
Compared to traditional cell lines, ITGA4 Gene Knockout Cell Lines possess distinct advantages, including reduced background noise in experiments, focused investigations on specific pathways, and enhanced reproducibility of results. These cell lines are also customizable, allowing for the creation of variants to suit specific experimental conditions or hypotheses.
For researchers and clinicians alike, the value of ITGA4 Gene Knockout Cell Lines is significant. They not only facilitate the exploration of integrin function but also represent a step forward in the development of precision medicine strategies. By providing clearer insights into disease mechanisms, these models ultimately empower researchers to drive forward breakthrough discoveries and clinical advancements.
As a leader in the field of biological products, we are committed to delivering high-quality, innovative solutions that meet the rigorous demands of scientific inquiry. Our expertise in cell line development ensures that our ITGA4 Gene Knockout Cell Lines are both reliable and versatile, setting the stage for significant impactful research and therapeutic discovery.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.