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INVS Knockout Cell Lines

Gene: INVS

Official Full Name: inversinprovided by HGNC

Gene Summary: This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00169 INVS Knockout cell line (HEK293) Human INVS 1:3~1:6 Negative Online Inquiry
KO11746 INVS Knockout cell line (HeLa) Human INVS 1:3~1:6 Negative Online Inquiry
KO11747 INVS Knockout cell line (HCT 116) Human INVS 1:2~1:4 Negative Online Inquiry
KO11748 INVS Knockout cell line (A549) Human INVS 1:3~1:4 Negative Online Inquiry

Background

INVS Gene Knockout Cell Lines represent a cutting-edge biotechnological advancement designed for the targeted deletion of specific genes in mammalian cell lines. These cell lines are engineered using CRISPR-Cas9 technology, a revolutionary tool that allows for precise modifications at the genomic level. By creating knockout models, researchers can elucidate gene function and elucidate gene-disease relationships effectively.

The key function of the INVS Gene Knockout Cell Lines lies in their ability to disable targeted genes. The CRISPR-Cas9 system introduces double-stranded breaks in the DNA, which, upon cellular repair, leads to insertions or deletions that disrupt the open reading frame of the target gene. This results in a loss of gene function, allowing researchers to investigate the biological and pathological roles of specific genes in vitro. The versatility of these cell lines extends to various applications, ranging from drug discovery and toxicology to fundamental research in genetics and cell biology.

Scientists and clinicians engage with these knockout models to gain insights into disease mechanisms, particularly in cancer, neurobiology, and metabolic disorders. The ability to study the effects of gene loss in a controlled environment paves the way for discovering new therapeutic targets and personalized medicine approaches.

What sets INVS Gene Knockout Cell Lines apart from competing products is their robust validation and documentation, ensuring reliability and reproducibility in experimental outcomes. Our commitment to reducing variability maximizes experimental efficiency, allowing researchers to achieve meaningful results with confidence. Additionally, these cell lines come with extensive technical support and are compatible with a range of assays, providing users with versatility and peace of mind.

In summary, the value of INVS Gene Knockout Cell Lines extends beyond mere research utility—they are essential tools that drive innovation in gene function studies and foster breakthroughs in clinical applications. Our company, with a dedicated team of experts and a deep commitment to advancing biological sciences, delivers high-quality products that facilitate groundbreaking research across the globe.

Please note that all services are for research use only. Not intended for any clinical use.

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