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INTS10 Knockout Cell Lines

Gene: INTS10

Official Full Name: integrator complex subunit 10provided by HGNC

Gene Summary: INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16905 INTS10 Knockout cell line (HeLa) Human INTS10 1:3~1:6 Negative Online Inquiry
KO16906 INTS10 Knockout cell line (HCT 116) Human INTS10 1:2~1:4 Negative Online Inquiry
KO16907 INTS10 Knockout cell line (HEK293) Human INTS10 1:3~1:6 Negative Online Inquiry

Background

INTS10 Gene Knockout Cell Lines are meticulously engineered cellular models that lack the expression of the INTS10 gene, which encodes for a pivotal component of the Integrator complex involved in RNA processing and gene expression regulation. These knockout cell lines serve as a crucial tool for dissecting the functional roles of INTS10 in various biological processes, such as transcription termination, mRNA splicing, and the regulation of gene expression in response to cellular stimuli.

The mechanism of action relies on the complete deletion of the INTS10 gene, achieved through advanced CRISPR/Cas9 gene-editing technology. By creating a clean genetic knockout, researchers can observe the resultant phenotypic and molecular changes, elucidating the gene's contribution to cellular pathways. This model can aid in the identification of downstream effects on mRNA synthesis and splicing, providing insights into the complex regulatory networks governing gene expression.

INTS10 Gene Knockout Cell Lines hold significant scientific importance in both fundamental research and translational applications. In academic and clinical settings, they enable researchers to study diseases associated with dysregulation of RNA processing, such as certain cancers and neurodegenerative disorders. Their application spans drug discovery, where understanding the role of INTS10 may reveal new therapeutic targets, to biotechnology, where manipulating gene expression can lead to advancements in synthetic biology.

What sets INTS10 Gene Knockout Cell Lines apart from traditional knockout models is the precision and efficiency of their creation. The CRISPR technology ensures not only accuracy in gene editing but also reproducibility across experiments. Moreover, these cell lines are validated for consistent performance and compatibility with various assays, making them ideal for high-throughput screening.

These distinctive attributes make INTS10 Gene Knockout Cell Lines invaluable tools for researchers and clinicians seeking to deepen our understanding of gene function and its implications in health and disease. Our company specializes in providing high-quality biological products, leveraging state-of-the-art gene editing techniques to support scientific exploration and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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