Gene: ING5
Official Full Name: inhibitor of growth family member 5provided by HGNC
Gene Summary: This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24971 | ING5 Knockout cell line (HeLa) | Human | ING5 | 1:3~1:6 | Negative | Online Inquiry |
KO24972 | ING5 Knockout cell line (HCT 116) | Human | ING5 | 1:2~1:4 | Negative | Online Inquiry |
KO24973 | ING5 Knockout cell line (HEK293) | Human | ING5 | 1:3~1:6 | Negative | Online Inquiry |
KO24974 | ING5 Knockout cell line (A549) | Human | ING5 | 1:3~1:4 | Negative | Online Inquiry |
ING5 Gene Knockout Cell Lines are meticulously developed cellular models that enable researchers to explore the functional implications of the ING5 gene by creating a genetic absence of this specific gene. The ING5 protein is predominantly involved in chromatin remodeling and is implicated in various cellular processes such as regulation of gene expression, cell cycle control, and apoptosis. By utilizing these knockout cell lines, scientists can effectively elucidate the various roles and pathways associated with ING5, enhancing our understanding of its contributions to tumor biology and other diseases.
The key mechanism by which ING5 Gene Knockout Cell Lines operate involves the complete deletion of the ING5 gene through targeted gene editing technologies, such as CRISPR/Cas9. This results in a loss-of-function model that allows researchers to delineate the phenotypic changes arising from the absence of ING5, contributing to a better understanding of its role in oncogenesis and cellular response to stressors. These models are essential in academic and pharmaceutical research settings for dissecting the pathways in which ING5 may play a critical role.
The scientific importance of ING5 Gene Knockout Cell Lines extends to their applications in both research and clinical settings. They serve as powerful tools for understanding the molecular underpinnings of various diseases, thereby facilitating the discovery of potential therapeutic targets. Furthermore, their application in drug development and testing provides vital insight into the efficacy and safety of new anticancer agents that may modulate ING5 activity.
Compared to alternative models, such as wild-type cell lines or transient transfection approaches, ING5 Gene Knockout Cell Lines offer a stable and consistent platform for long-term studies, reducing variability and enhancing reproducibility. Their robustness enhances their applicability across a range of experimental designs, which is a significant advantage for researchers demanding precision and reliability in their work.
For researchers and clinicians alike, the value of ING5 Gene Knockout Cell Lines lies in their potential to drive significant advancements in the understanding of ING5-related pathways and their implications in health and disease. As an integral part of our product offering, our company’s experience in developing high-grade biological products ensures that these cell lines are rigorously validated and backed by extensive support to meet the highest research standards. By choosing ING5 Gene Knockout Cell Lines, researchers gain access to a critical resource for innovative discoveries and impactful translational research.
Please note that all services are for research use only. Not intended for any clinical use.
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