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IMPA1 Knockout Cell Lines

Gene: IMPA1

Official Full Name: inositol monophosphatase 1provided by HGNC

Gene Summary: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07792 IMPA1 Knockout cell line (HeLa) Human IMPA1 1:3~1:6 Negative Online Inquiry
KO07793 IMPA1 Knockout cell line (HCT 116) Human IMPA1 1:2~1:4 Negative Online Inquiry
KO07794 IMPA1 Knockout cell line (HEK293) Human IMPA1 1:3~1:6 Negative Online Inquiry
KO07795 IMPA1 Knockout cell line (A549) Human IMPA1 1:3~1:4 Negative Online Inquiry

Background

IMPA1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to disrupt the expression of the IMPA1 gene, which encodes inositol monophosphatase 1, an important enzyme in inositol phosphate metabolism. By knocking out this gene, researchers can study the role of inositol signaling pathways and their implications in various physiological and pathological processes, including cell signaling, neuronal function, and metabolic disorders.

The key function of these knockout cell lines lies in their ability to provide a controlled environment to investigate the biological consequences of IMPA1 gene deletion. The absence of the IMPA1 gene allows researchers to explore altered inositol recycling and its downstream effects on signaling cascades. This targeted approach not only facilitates a deeper understanding of the gene's biological role but also aids in elucidating its potential contributions to diseases such as bipolar disorder and cancer.

The scientific importance of IMPA1 Gene Knockout Cell Lines is evident in their applications in both research and clinical settings. They serve as valuable tools for drug discovery, particularly in identifying new therapeutic targets that can modulate inositol signaling. Furthermore, these cell lines can facilitate the development of biomarkers for diseases associated with dysregulated inositol metabolism, thereby advancing personalized medicine approaches.

Compared to conventional cell lines, IMPA1 Gene Knockout Cell Lines offer a unique advantage by providing an unambiguous model to study the consequences of specific gene loss. This specificity minimizes confounding variables often present in wild-type models, leading to more robust and reproducible results.

For researchers and clinicians, the value of these knockout cell lines lies in their ability to provide insights into disease mechanisms and therapeutic strategies in a nuanced and focused manner. They empower scientists to engineer experiments around specific hypotheses regarding the IMPA1 gene's role, enhancing the potential for groundbreaking discoveries.

With a strong foundation in molecular biology and extensive experience in developing genetically modified cell lines, our company is committed to advancing research in innovative ways. By providing high-quality IMPA1 Gene Knockout Cell Lines, we support the research community in unraveling complex biological systems and their implications in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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