Gene: IL17RD
Official Full Name: interleukin 17 receptor Dprovided by HGNC
Gene Summary: This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20565 | IL17RD Knockout cell line (HCT 116) | Human | IL17RD | 1:2~1:4 | Negative | Online Inquiry |
KO20566 | IL17RD Knockout cell line (HEK293) | Human | IL17RD | 1:3~1:6 | Negative | Online Inquiry |
KO20567 | IL17RD Knockout cell line (A549) | Human | IL17RD | 1:3~1:4 | Negative | Online Inquiry |
IL17RD Gene Knockout Cell Lines are specifically engineered cell lines characterized by the targeted disruption of the IL17RD gene, a critical player in mediating immune responses and inflammation. By utilizing advanced CRISPR-Cas9 technology, these knockout cell lines facilitate the elucidation of the functional roles of IL17RD in various pathological conditions, particularly those related to autoimmune diseases and cancers where aberrant IL-17 signaling is implicated.
The key mechanisms of IL17RD involve its regulation of downstream signaling pathways, notably the NF-kB and MAPK pathways, which are crucial for cytokine production and inflammatory response. By knocking out IL17RD, researchers can observe downstream effects, thereby gaining insights into cellular behavior, cytokine profiles, and potential resistance mechanisms to therapeutic agents. Such insights are invaluable in both fundamental and translational research, allowing for the identification of novel therapeutic targets.
In clinical and research applications, the IL17RD Gene Knockout Cell Lines serve as essential tools for drug discovery, providing a platform for screening potential anti-inflammatory and anti-cancer agents. They also enable the study of immune cell interactions and the modulation of tissue responses in in vitro and in vivo contexts, solidifying their role in advancing immunological research.
What sets our IL17RD knockout cell lines apart from alternatives is their high specificity, reproducibility, and the comprehensive validation for effective IL17RD disruption. The availability of characterized phenotypes allows users to draw reliable conclusions swiftly. Furthermore, our product is supported by extensive technical documentation and customer service, ensuring users can optimize their research outcomes.
By choosing our IL17RD Gene Knockout Cell Lines, researchers and clinicians can confidently advance their studies of immune regulation and disease pathology. Our company boasts an unparalleled commitment to quality and innovation, leveraging years of expertise in the field of genetic engineering to provide cutting-edge biological tools tailored to meet the challenging demands of modern research.
Please note that all services are for research use only. Not intended for any clinical use.
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