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IGF2BP3 Knockout Cell Lines

Gene: IGF2BP3

Official Full Name: insulin like growth factor 2 mRNA binding protein 3provided by HGNC

Gene Summary: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00428 IGF2BP3 gRNA3-gRNA4 KO plasmid IGF2BP3 $850
GP00540 IGF2BP3 gRNA1-gRNA2 KO plasmid IGF2BP3 $850
KO00196 IGF2BP3 Knockout cell line (HCT 116) Human IGF2BP3 1:2~1:4 Negative Online Inquiry
KO00701 IGF2BP3 Knockout cell line(ACHN) Human IGF2BP3 1:2~1:3 Negative Online Inquiry
KO00947 IGF2BP3 Knockout cell line(HEK293) Human IGF2BP3 1:3~1:6 Negative Online Inquiry
KO16987 IGF2BP3 Knockout cell line (HeLa) Human IGF2BP3 1:3~1:6 Negative Online Inquiry
KO16988 IGF2BP3 Knockout cell line (A549) Human IGF2BP3 1:3~1:4 Negative Online Inquiry

Background

IGF2BP3 Gene Knockout Cell Lines are genetically modified cell lines designed specifically to study the effects and functions of the IGF2BP3 gene, known for its role in regulating cellular growth, proliferation, and differentiation. By utilizing CRISPR/Cas9 technology for precise gene editing, these knockout cell lines offer researchers a robust platform for investigating the biological implications of IGF2BP3 depletion on various cellular processes.

The primary function of IGF2BP3 involves modulating the stability and translation of mRNAs, predominantly those linked to growth and oncogenesis. By knocking out this gene, scientists can dissect its role in cancer biology, developmental processes, and metabolic regulation by elucidating downstream signaling pathways activated in the absence of IGF2BP3. The ability to generate a variety of cell lines, tailored for specific tissue types or disease states, enhances the versatility of these models for both fundamental research and therapeutic exploration.

The scientific importance of IGF2BP3 knockout cell lines cannot be overstated as they provide valuable insights into the molecular drivers of numerous diseases, including various cancers and metabolic disorders. Their applications range from drug discovery and target validation to understanding resistance mechanisms in cancer therapies.

Compared to traditional knockout models that may require extensive breeding and validation, our IGF2BP3 Gene Knockout Cell Lines provide a faster, more reliable, and ethically conscious solution. They ensure consistent expression profiles and facilitate reproducibility across experiments, minimizing variability associated with biological models.

For researchers and clinicians alike, the value of these knockout cell lines lies in their capacity to accelerate the understanding of gene function while offering a streamlined avenue for translational research. Engaging with our products grants access to advanced cellular models backed by years of expertise in genetic engineering and biological research, ensuring that your studies are grounded in innovative science.

Please note that all services are for research use only. Not intended for any clinical use.

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