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IGF2BP2 Knockout Cell Lines

Gene: IGF2BP2

Official Full Name: insulin like growth factor 2 mRNA binding protein 2provided by HGNC

Gene Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00575 IGF2BP2 gRNA1-gRNA2 KO plasmid IGF2BP2 $850
GP00712 IGF2BP2 gRNA3-gRNA4 KO plasmid IGF2BP2 $850
GP00716 IGF2BP2 gRNA1-gRNA2 KO plasmid IGF2BP2 $850
KO00580 IGF2BP2 Knockout cell line(786-O) Human IGF2BP2 1:2-1:4 Negative Online Inquiry
KO00875 IGF2BP2 Knockout cell line(HSC3) Human IGF2BP2 1:3~1:5 Negative Online Inquiry
KO00955 IGF2BP2 Knockout cell line(HEK293) Human IGF2BP2 1:3~1:6 Negative Online Inquiry
KO16989 IGF2BP2 Knockout cell line (HeLa) Human IGF2BP2 1:3~1:6 Negative Online Inquiry
KO16990 IGF2BP2 Knockout cell line (HCT 116) Human IGF2BP2 1:2~1:4 Negative Online Inquiry
KO16991 IGF2BP2 Knockout cell line (A549) Human IGF2BP2 1:3~1:4 Negative Online Inquiry

Background

IGF2BP2 Gene Knockout Cell Lines are specially curated cellular models that have been genetically modified to eliminate the expression of the Insulin-like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2). This product serves as a fundamental investigative tool in molecular biology, particularly for studying the gene's role in cellular processes, such as growth regulation, differentiation, and the intricate mechanisms of metabolic disorders. By employing CRISPR-Cas9 technology, these cell lines provide a precisely targeted approach to gene disruption, facilitating detailed examination of the downstream effects of IGF2BP2 loss.

The primary function of the IGF2BP2 gene is to bind and stabilize certain mRNAs, influencing their translation and, subsequently, cellular protein levels. When this gene is knocked out, researchers can uncover the resulting changes in cellular behavior, gene expression profiles, and metabolic pathways. These insights are crucial for understanding IGF2BP2's role in diseases like diabetes and cancer, providing a basis for potential therapeutic strategies.

In scientific research and clinical settings, IGF2BP2 Gene Knockout Cell Lines are invaluable for validating hypotheses regarding gene function and interactions. Their utility extends to drug discovery and the assessment of candidate therapeutics aimed at modulating IGF2BP2-related pathways. Compared to other genetic disruption methods, such as traditional knockdown approaches, our knockout cell lines offer a stable and complete loss of function, ensuring that researchers receive reliable and reproducible results.

Moreover, these cell lines are derived from widely used human cancer cell models, which helps promote the translational potential of findings. Researchers, clinicians, and pharmaceutical developers will find the IGF2BP2 Gene Knockout Cell Lines exceptional for advancing their studies and understanding complex biological systems.

Our company prides itself on delivering high-quality, reliable biological products, with a team of experts dedicated to supporting innovation in research. By utilizing our IGF2BP2 Gene Knockout Cell Lines, you gain access to cutting-edge technology that enhances your experimental design and fosters significant scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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