Gene: IFNLR1
Official Full Name: interferon lambda receptor 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06649 | IFNLR1 Knockout cell line (HeLa) | Human | IFNLR1 | 1:3~1:6 | Negative | Online Inquiry |
KO06650 | IFNLR1 Knockout cell line (HCT 116) | Human | IFNLR1 | 1:2~1:4 | Negative | Online Inquiry |
KO06651 | IFNLR1 Knockout cell line (HEK293) | Human | IFNLR1 | 1:3~1:6 | Negative | Online Inquiry |
KO06652 | IFNLR1 Knockout cell line (A549) | Human | IFNLR1 | 1:3~1:4 | Negative | Online Inquiry |
IFNLR1 Gene Knockout Cell Lines are meticulously engineered cellular models designed to study the interleukin-28 receptor, also known as the type III interferon receptor. This receptor plays a crucial role in the immune response and is a key component in viral defense mechanisms. By knocking out the IFNLR1 gene, these cell lines allow researchers to investigate pathways involved in antigen recognition and subsequent immune responses, particularly in the context of viral infections and other immune-mediated diseases.
The primary function of IFNLR1 Gene Knockout Cell Lines is to facilitate the analysis of the biological roles and molecular interactions of the interleukin-28 signaling pathway. By observing how the absence of this receptor affects cellular behavior, scientists can elucidate its implications in host-pathogen interactions, antiviral responses, and potential therapeutic interventions. The knockout model enables the identification of compensatory signaling mechanisms and the assessment of cellular responses under conditions where type III interferon signaling is disrupted.
The scientific importance of these cell lines is evident in their diverse applications within research and clinical settings. They serve as valuable tools in the study of viral pathogenesis, the development of novel antiviral therapeutics, and the exploration of immune deficiencies linked to IFNLR1 signaling disruptions. Understanding these pathways can also yield insights into potential biomarkers for patient stratification in personalized medicine approaches.
What sets IFNLR1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability in investigating the nuances of type III interferon biology. Traditional models often employ non-targeted gene editing approaches or lack the necessary control over experimental conditions. In contrast, these knockout lines provide a consistent and reproducible platform for experimental validation and hypothesis testing, ensuring that researchers can derive meaningful conclusions from their studies.
The value of IFNLR1 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to provide crucial insights into immune responses, paving the way for the development of innovative therapeutic strategies. These cell lines support advanced research initiatives that can significantly impact therapeutic drug development, vaccine responses, and the understanding of immune-related pathologies.
Our company is committed to advancing scientific research through high-quality biological products such as IFNLR1 Gene Knockout Cell Lines. With a focus on precision and reliability, we aim to equip researchers with the tools necessary to unlock new discoveries in the field of immunology and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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