Gene: IFNL4
Official Full Name: interferon lambda 4 (gene/pseudogene)provided by HGNC
Gene Summary: This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20445 | IFNL4 Knockout cell line (HeLa) | Human | IFNL4 | 1:3~1:6 | Negative | Online Inquiry |
KO20446 | IFNL4 Knockout cell line (HCT 116) | Human | IFNL4 | 1:2~1:4 | Negative | Online Inquiry |
KO20447 | IFNL4 Knockout cell line (HEK293) | Human | IFNL4 | 1:3~1:6 | Negative | Online Inquiry |
KO20448 | IFNL4 Knockout cell line (A549) | Human | IFNL4 | 1:3~1:4 | Negative | Online Inquiry |
IFNL4 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the interferon lambda 4 (IFNL4) gene's role in immune responses and viral infections. These knockout cell lines are created via CRISPR-Cas9 gene-editing technology, which precisely disrupts the IFNL4 gene, allowing researchers to investigate the functional consequences of its absence on cellular behavior and response to pathogen exposure.
The IFNL4 gene encodes a type III interferon with significant implications for antiviral immunity, particularly in the context of hepatitis C and other viral infections. By utilizing these knockout cell lines, scientists can elucidate the signaling pathways activated by IFNL4 and how they influence the innate immune response. This understanding is critical for developing targeted therapeutics and vaccines, ultimately enhancing patient outcomes in various infectious diseases.
One of the primary advantages of IFNL4 Gene Knockout Cell Lines is their ability to provide a more accurate representation of human cellular processes compared to traditional laboratory models. This specificity enables researchers to generate insights that are directly applicable to clinical settings, potentially accelerating the discovery and optimization of novel treatments. Furthermore, these knockout models can save time and resources compared to in vivo studies, allowing for a more efficient research workflow.
The value of these cell lines to researchers and clinicians lies in their capacity to improve the understanding of disease mechanisms associated with IFNL4. By uncovering how the absence of this gene alters cellular and immune functions, researchers can better design experiments that inform therapeutic strategies.
Our company prides itself on its cutting-edge expertise in gene-editing technologies and its commitment to providing high-quality biological products. With a portfolio that supports groundbreaking research, we enable scientists and clinicians to explore the complexities of molecular biology with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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