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IFIH1 Knockout Cell Lines

Gene: IFIH1

Official Full Name: interferon induced with helicase C domain 1provided by HGNC

Gene Summary: IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00094 IFIH1 Knockout cell line (293T) Human IFIH1 1:3~1:6 Negative Online Inquiry
KO02057 IFIH1 Knockout cell line (HeLa) Human IFIH1 1:3~1:6 Negative Online Inquiry
KO02058 IFIH1 Knockout cell line (HCT 116) Human IFIH1 1:2~1:4 Negative Online Inquiry
KO02059 IFIH1 Knockout cell line (HEK293) Human IFIH1 1:3~1:6 Negative Online Inquiry
KO02060 IFIH1 Knockout cell line (A549) Human IFIH1 1:3~1:4 Negative Online Inquiry

Background

IFIH1 Gene Knockout Cell Lines represent a cutting-edge tool for studying the function of the interferon-induced helicase C domain 1 (IFIH1) gene, which plays a crucial role in the innate immune response to viral infections. These cell lines are engineered to have a complete knockout of the IFIH1 gene, allowing researchers to investigate the gene's regulatory pathways and its implications in autoimmune disorders and viral pathogenesis without interfering cellular interactions from the typical gene expression.

The primary mechanism of these cell lines involves the disruption of the IFIH1 pathway, enabling the study of alterations in cellular signaling in response to viral challenges. Researchers can analyze how the absence of IFIH1 affects the activation of downstream transcription factors like IRF3 and NF-κB, which are pivotal in the production of antiviral cytokines. This elucidates the gene's role in modulating immune responses, providing insights into the molecular mechanisms underpinning immune dysregulation in diseases such as systemic lupus erythematosus and other interferonopathies.

In clinical and research settings, the IFIH1 Gene Knockout Cell Lines are invaluable for elucidating the precise molecular interactions and cellular responses related to viral infections and inflammatory responses. By employing these knockout models, researchers can develop potential therapies targeting the IFIH1 pathway, contributing to novel treatment strategies for viral diseases and related immune disorders.

What sets our IFIH1 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, validated through rigorous testing. They offer researchers the unique advantage of investigating gene function in a controlled environment, thus mitigating the confounding effects often seen with wild-type models.

The value of this product lies in its ability to empower researchers and clinicians with a reliable model that enhances their understanding of the IFIH1 gene's role in health and disease. This not only accelerates the pace of discovery but also aids in the translation of findings into therapeutic applications.

Backed by years of expertise in genetic engineering and cell line development, our company is committed to providing high-quality biological products that meet the rigorous demands of the scientific community. Our IFIH1 Gene Knockout Cell Lines are meticulously designed to ensure reproducibility and reliability, making them an essential addition to your research toolkit.

Please note that all services are for research use only. Not intended for any clinical use.

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