Gene: ID2
Official Full Name: inhibitor of DNA binding 2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11543 | ID2 Knockout cell line (HeLa) | Human | ID2 | 1:3~1:6 | Negative | Online Inquiry |
KO11544 | ID2 Knockout cell line (HCT 116) | Human | ID2 | 1:2~1:4 | Negative | Online Inquiry |
KO11545 | ID2 Knockout cell line (HEK293) | Human | ID2 | 1:3~1:6 | Negative | Online Inquiry |
KO11546 | ID2 Knockout cell line (A549) | Human | ID2 | 1:3~1:4 | Negative | Online Inquiry |
ID2 Gene Knockout Cell Lines are advanced biological tools designed for studying the essential functions of the ID2 gene in various cellular processes. The ID2 gene encodes an inhibitor of DNA binding proteins, which plays a critical role in cellular differentiation, proliferation, and the development of different tissues. By utilizing CRISPR/Cas9 technology, these cell lines have been precisely engineered to lack functional ID2 expression, allowing researchers to investigate the gene's role in oncogenesis, cell signaling pathways, and developmental biology.
These cell lines are invaluable in elucidating the specific mechanisms through which ID2 regulates cellular functions. They provide researchers with a unique platform to explore the consequences of ID2 knockout, furthering our understanding of its involvement in tumor biology, particularly in cancer types where ID2 is known to be overexpressed. The ability to perform comparative analyses with isogenic cell lines aids in the exploration of potential therapeutic targets and biomarkers for clinical applications.
Compared to traditional methods of gene knockdown, such as RNA interference, ID2 Gene Knockout Cell Lines offer a more stable and permanent genetic alteration, facilitating long-term studies of gene function. Moreover, these cell lines save significant time and resources by providing a consistent model that eliminates variability often associated with transient transfection techniques.
Researchers and clinicians will find outstanding value in these cell lines as they bridge the gap between basic research and clinical implications. Understanding the functional role of ID2 can lead to novel therapeutic interventions, particularly in cancer treatment strategies targeting pathways related to stemness and differentiation.
As a leader in the field of genetic engineering and cell line development, our company is committed to providing high-quality products and cutting-edge solutions for the scientific community. Our expertise ensures that researchers receive reliable and reproducible tools that can advance their investigations and contribute meaningfully to the advancement of medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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