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Hc Knockout Cell Lines

Gene: Hc

Official Full Name: hemolytic complementprovided by MGI

Gene Summary: This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00704 Hc gRNA3-gRNA4 KO plasmid Hc $850
GP00709 Hc gRNA1-gRNA2 KO plasmid Hc $850
KO01196 Hc Knockout cell line(H22) Mouse Hc 1:2-1:5 Negative Online Inquiry

Background

Hc Gene Knockout Cell Lines are highly specialized cellular models designed for gene function analysis, facilitating the study of specific gene roles in various biological processes. These cell lines are generated through advanced genetic engineering techniques, such as CRISPR-Cas9, resulting in the precise deletion of target genes. As a result, researchers can investigate the implications of gene loss on cellular functions, signaling pathways, and disease mechanisms, providing a powerful platform for functional genomics studies.

The key function of Hc Gene Knockout Cell Lines lies in their ability to harbor controlled genetic modifications that enable scientists to delineate the roles of individual genes within complex biological systems. This is particularly valuable in fields such as cancer research, drug discovery, and developmental biology, where understanding the nuances of gene function can lead to breakthroughs in therapeutic strategies. By analyzing the phenotypic consequences of gene knockout, researchers can uncover essential insights into gene regulation, cellular adaptation, and disease etiology.

The scientific importance of these cell lines extends to their utility in preclinical studies, as knockout models can simulate human disease states, offering valuable output for therapeutic development. Moreover, these cell lines can serve as platforms for high-throughput screening of potential drug candidates, allowing rapid identification of gene-targeted therapies.

Unique advantages of Hc Gene Knockout Cell Lines include their high specificity and reproducibility in genetic modifications, which surpasses traditional knockout methods, such as homologous recombination. Additionally, Hc cell lines are engineered with robust selection markers, ensuring the stability of the knockout phenotype over extended culture periods. Unlike other cellular models, these knockout lines can be tailored to individual research needs, enhancing experimental relevance and flexibility.

By incorporating Hc Gene Knockout Cell Lines into research protocols, scientists can accelerate their investigations into gene function, potentially leading to significant medical advancements. Our commitment to quality in producing these cell lines underscores our expertise in genetic engineering and cell line development, providing researchers and clinicians with reliable tools to advance their work in the biomedical field.

Please note that all services are for research use only. Not intended for any clinical use.

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