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HPS4 Knockout Cell Lines

Gene: HPS4

Official Full Name: HPS4 biogenesis of lysosomal organelles complex 3 subunit 2provided by HGNC

Gene Summary: This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23947 HPS4 Knockout cell line (HeLa) Human HPS4 1:3~1:6 Negative Online Inquiry
KO23948 HPS4 Knockout cell line (HCT 116) Human HPS4 1:2~1:4 Negative Online Inquiry
KO23949 HPS4 Knockout cell line (HEK293) Human HPS4 1:3~1:6 Negative Online Inquiry
KO23950 HPS4 Knockout cell line (A549) Human HPS4 1:3~1:4 Negative Online Inquiry

Background

HPS4 Gene Knockout Cell Lines are specialized cellular models created through advanced gene editing techniques to specifically disrupt the expression of the HPS4 gene, which is critical in lysosomal function and related cellular pathways. These cell lines allow researchers to study the functional consequences of HPS4 gene loss and investigate its implications in various biological processes and diseases, particularly those related to lysosomal storage disorders.

The primary function of HPS4 Gene Knockout Cell Lines is to provide a platform for understanding the role of HPS4 in cellular physiology. By knocking out the HPS4 gene, these cell lines enable the investigation of lysosomal integrity, autophagy, and intracellular transport mechanisms. Researchers can assess changes in cellular metabolism, enzyme activity, and protein trafficking pathways, gaining insights into how disruptions in lysosomal function contribute to disease pathology.

The scientific importance of HPS4 Gene Knockout Cell Lines extends beyond basic research; they serve as vital tools for drug discovery and therapeutic development. In clinical settings, these cell lines can be leveraged to identify potential therapeutic targets and evaluate drug candidates aimed at mitigating effects associated with HPS4 deficiencies. Moreover, they can also be employed in the validation of gene therapies designed to rescue HPS4 function in affected cells.

What sets HPS4 Gene Knockout Cell Lines apart from traditional cell models is their specificity and reliability. Unlike alternative models that may exhibit variable gene expression or abnormalities unrelated to HPS4, these knockout lines offer a grounded system with a well-characterized genetic background, ensuring reproducibility in experimental results. This specificity is crucial for researchers seeking high-quality data in their investigations.

For researchers and clinicians, investing in HPS4 Gene Knockout Cell Lines translates to access to cutting-edge models that provide deeper understanding and insights into lysosomal functions and associated disease mechanisms. Whether for fundamental research or preclinical studies, these cell lines empower users with robust experimental tools that advance the field of medical research.

Our company specializes in high-quality biological products and has extensive expertise in creating and characterizing gene knockout models that drive innovation in research and therapeutic development. With a commitment to precision and reliability, we support the scientific community with products that enhance discovery and understanding in cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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