Gene: HOXA7
Official Full Name: homeobox A7provided by HGNC
Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37297 | HOXA7 Knockout cell line (HeLa) | Human | HOXA7 | 1:3~1:6 | Negative | Online Inquiry |
KO37298 | HOXA7 Knockout cell line (HCT 116) | Human | HOXA7 | 1:2~1:4 | Negative | Online Inquiry |
KO37299 | HOXA7 Knockout cell line (HEK293) | Human | HOXA7 | 1:3~1:6 | Negative | Online Inquiry |
KO37300 | HOXA7 Knockout cell line (A549) | Human | HOXA7 | 1:3~1:4 | Negative | Online Inquiry |
HOXA7 Gene Knockout Cell Lines are genetically engineered models that provide researchers with a powerful tool for studying the functional role of the HOXA7 gene, which is implicated in various developmental processes and pathologies, including cancer. These cell lines have been meticulously designed to facilitate the investigation of HOXA7's contributions to gene regulation and cellular differentiation by enabling precise knockout of the gene through advanced CRISPR-Cas9 technology.
The key function of the HOXA7 Gene Knockout Cell Lines lies in their ability to create a controlled environment where the expression of the HOXA7 gene is effectively silenced, allowing for the observation of phenotypic changes and molecular pathways activated in its absence. Researchers can employ these models to elucidate the downstream effects of HOXA7 deletion, including impacts on cell proliferation, apoptosis, and migration. This mechanistic insight has profound implications for understanding the gene's role in oncogenesis, particularly in cancers where HOXA7 is overexpressed.
In terms of scientific importance, these cell lines enhance our understanding of gene regulatory networks in both fundamental biology and translational research. The ability to investigate the role of HOXA7 in a controlled setting holds significant promise for discovering novel therapeutic targets or developing strategies for more personalized medicine approaches, especially in tumor biology.
What sets our HOXA7 Gene Knockout Cell Lines apart from alternative products on the market is their high fidelity and comprehensive characterization. Each cell line is validated for the complete absence of HOXA7 expression, ensuring reliability in experimental outcomes. Additionally, our product comes with a complete support package, including user-friendly protocols and expert consultation, helping researchers optimize their use of the cell lines.
For researchers and clinicians, these knockout cell lines represent a critical advancement in studying gene function and developing new therapeutic avenues. By offering a unique window into the biology of HOXA7 and its interactions within the cellular milieu, these models empower users to drive research forward with confidence.
At our company, we pride ourselves on our commitment to advancing scientific inquiry by providing high-quality biological tools and cell lines, developed and validated by experts in genetic engineering. Our extensive experience in the field ensures that clients receive not only superior products but also dedicated support throughout their research journey.
Please note that all services are for research use only. Not intended for any clinical use.
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