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HOMER2 Knockout Cell Lines

Gene: HOMER2

Official Full Name: homer scaffold protein 2provided by HGNC

Gene Summary: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08207 HOMER2 Knockout cell line (HeLa) Human HOMER2 1:3~1:6 Negative Online Inquiry
KO08208 HOMER2 Knockout cell line (HEK293) Human HOMER2 1:3~1:6 Negative Online Inquiry
KO08209 HOMER2 Knockout cell line (A549) Human HOMER2 1:3~1:4 Negative Online Inquiry

Background

HOMER2 Gene Knockout Cell Lines are genetically engineered cell lines in which the HOMER2 gene has been selectively disrupted. This innovative biotechnological product is designed to facilitate the study of the functions and pathways associated with HOMER2, a critical gene involved in synaptic signaling and neurotransmission. By utilizing CRISPR/Cas9 or similar gene-editing technologies, these cell lines enable researchers to observe the phenotypic consequences of HOMER2 loss-of-function, providing insights into various neurobiological processes and potential therapeutic strategies.

The key mechanism of these knockout cell lines involves the precise editing of the HOMER2 gene, resulting in the complete absence of its protein product. Researchers can utilize these cell lines to investigate the effects of HOMER2 on synaptic plasticity, learning, and memory, as well as its role in neurodegenerative diseases or psychiatric disorders, making them invaluable tools in both basic and applied research.

Scientifically, HOMER2 Gene Knockout Cell Lines hold significant importance for investigations into synaptic dysfunction, as dysregulation of synaptic signaling pathways is often implicated in various neurological conditions. The application of these cell lines spans across molecular biology, pharmacology, and neuroscience, making them ideal for drug development and validation or for screening potential therapeutic compounds.

Compared to conventional methods of studying gene function, such as knockdown approaches (e.g., RNA interference), the HOMER2 Gene Knockout Cell Lines offer a more stable and permanent genetic alteration. This ensures that observed changes in cellular behavior are directly related to the absence of HOMER2, providing clearer insights into gene function and protein interactions without the confounding effects of residual gene expression.

Investing in HOMER2 Gene Knockout Cell Lines empowers researchers and clinicians with the tools necessary to deepen their understanding of complex neurological processes and explore new avenues for treatment. A deeper exploration of these innovative cell lines could pave the way for breakthroughs in therapeutic approaches for diseases involving synaptic dysfunction.

Our company specializes in high-quality biological products backed by extensive research and development, demonstrating our commitment to providing researchers and clinicians with the most accurate and effective tools available in the market. With a focus on advancing scientific exploration, we ensure our offerings continually meet the highest standards of quality and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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