Gene: HLA-F
Official Full Name: major histocompatibility complex, class I, Fprovided by HGNC
Gene Summary: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17086 | HLA-F Knockout cell line (HeLa) | Human | HLA-F | 1:3~1:6 | Negative | Online Inquiry |
KO17087 | HLA-F Knockout cell line (HCT 116) | Human | HLA-F | 1:2~1:4 | Negative | Online Inquiry |
KO17088 | HLA-F Knockout cell line (HEK293) | Human | HLA-F | 1:3~1:6 | Negative | Online Inquiry |
KO17089 | HLA-F Knockout cell line (A549) | Human | HLA-F | 1:3~1:4 | Negative | Online Inquiry |
HLA-F Gene Knockout Cell Lines are genetically engineered cell lines designed to enable the detailed study of the HLA-F gene's function and its role in immune response and disease progression. By utilizing CRISPR-Cas9 gene editing technology, these cell lines have been developed to lack functional copies of the HLA-F gene, allowing researchers to observe the physiological and biochemical changes that occur when this gene is inactive.
The primary function of HLA-F is to encode a protein that participates in the presentation of antigens to immune cells, a vital process for immune surveillance and response. By employing HLA-F Gene Knockout Cell Lines, scientists can investigate the cellular mechanisms underlying immune recognition and wastage by examining how the absence of HLA-F influences cell signaling, antigen processing, and immune cell interactions.
The scientific importance of these cell lines lies in their applications across various research domains, including immunology, oncology, and virology. By providing a platform for studying the inherent biology of the HLA-F gene, researchers can explore its implications in autoimmune diseases, infection responses, and cancer immunotherapy, potentially leading to novel therapeutic strategies.
Compared to alternative cell models, HLA-F Gene Knockout Cell Lines offer unique advantages, including the specificity of complete gene knockout without residual expression and the versatility to be used in a wide array of experimental setups. This precision allows for the generation of more reliable and reproducible data, ultimately enhancing the quality of research findings.
For researchers and clinicians focused on understanding complex immunological pathways and developing targeted therapies, HLA-F Gene Knockout Cell Lines represent an invaluable tool that accelerates discovery and innovation. Our company, with its expertise in producing high-quality biological products, is committed to providing these advanced cell lines, empowering the scientific community to tackle pressing health challenges.
Please note that all services are for research use only. Not intended for any clinical use.
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