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HIPK1 Knockout Cell Lines

Gene: HIPK1

Official Full Name: homeodomain interacting protein kinase 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01590 HIPK1 Knockout cell line (HeLa) Human HIPK1 1:3~1:6 Negative Online Inquiry
KO01591 HIPK1 Knockout cell line (HCT 116) Human HIPK1 1:2~1:4 Negative Online Inquiry
KO01592 HIPK1 Knockout cell line (HEK293) Human HIPK1 1:3~1:6 Negative Online Inquiry
KO01593 HIPK1 Knockout cell line (A549) Human HIPK1 1:3~1:4 Negative Online Inquiry

Background

HIPK1 Gene Knockout Cell Lines are specialized cell lines created through the targeted disruption of the Homeodomain Interacting Protein Kinase 1 (HIPK1) gene. This gene plays a critical role in various cellular processes, including apoptosis, differentiation, and cell signaling pathways, making these knockout cell lines an essential tool for researchers investigating the function of HIPK1 in various biological contexts.

The key function of HIPK1 Gene Knockout Cell Lines involves the elimination of HIPK1 expression, which allows for the examination of downstream effects on cellular behavior and signaling pathways. Researchers can utilize these cell lines to unravel the pleiotropic effects of HIPK1 ablation, facilitating the study of its roles in cancer progression, immune response, and neurodegenerative diseases. The precise genetic modification creates a valuable resource for model systems that mimic pathophysiological states associated with HIPK1 dysregulation.

The scientific importance of these cell lines is underscored by their applications in both basic research and clinical settings. They enable scientists to investigate therapeutic targets and biomarkers while providing insight into disease mechanisms involving HIPK1. Moreover, the data derived from experiments using these cell lines can significantly contribute to the development of HIPK1-targeted therapies.

One of the standout advantages of our HIPK1 Gene Knockout Cell Lines is their high fidelity and reproducibility, ensuring that findings are both reliable and significant. Unlike traditional methods, which may rely on pharmacological inhibitors, our genetically modified cell lines offer a more specific approach by eliminating the gene entirely, thus avoiding off-target effects observed in pharmacological strategies.

For researchers and clinicians focused on the mechanisms of disease and therapeutic development, HIPK1 Gene Knockout Cell Lines provide an invaluable resource, allowing for more precise experimental designs and interpretations. With our company's background in providing advanced biological research products, we are committed to delivering high-quality solutions, enabling breakthrough discoveries and improved therapeutic insights in the complex field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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