Gene: HDGFL2
Official Full Name: HDGF like 2provided by HGNC
Gene Summary: This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24687 | HDGFL2 Knockout cell line (HeLa) | Human | HDGFL2 | 1:3~1:6 | Negative | Online Inquiry |
KO24688 | HDGFL2 Knockout cell line (HCT 116) | Human | HDGFL2 | 1:2~1:4 | Negative | Online Inquiry |
KO24689 | HDGFL2 Knockout cell line (HEK293) | Human | HDGFL2 | 1:3~1:6 | Negative | Online Inquiry |
KO24690 | HDGFL2 Knockout cell line (A549) | Human | HDGFL2 | 1:3~1:4 | Negative | Online Inquiry |
HDGFL2 Gene Knockout Cell Lines represent a significant advancement in molecular biology, specifically designed to facilitate the study of the HDGFL2 gene's role in cellular processes. These cell lines are genetically engineered to disrupt the HDGFL2 gene, enabling researchers to explore its function and implications in various biological contexts. By creating a controlled environment where the gene is ablated, scientists can investigate changes in cellular behavior, signaling pathways, and gene interactions, providing insights into developmental biology, cancer research, and therapeutic targets.
The HDGFL2 gene has been implicated in critical pathways related to cell proliferation and apoptosis, making its knockout particularly valuable. In these specially crafted cell lines, the absence of HDGFL2 allows for direct evaluation of its contribution to molecular mechanisms such as cell cycle regulation and stress response. This platform can be instrumental in elucidating the pathophysiological roles of HDGFL2 in diseases, offering a deeper understanding that could drive innovative therapeutic strategies.
One of the unique advantages of using HDGFL2 Gene Knockout Cell Lines is their specificity and reliability, as they provide a robust model for experimental reproducibility. Unlike transient knockdown methods, these stable knockout lines ensure prolonged and consistent expression profiles, making them ideal for long-term studies. Moreover, they are compatible with various assays—from drug screening to functional genomics—enhancing their utility in both academic and pharmaceutical research.
The scientific community stands to benefit immensely from the integration of HDGFL2 Gene Knockout Cell Lines into research protocols, as they offer a powerful tool for dissecting complex biological pathways linked to health and disease. By providing clearer insights into the function of HDGFL2, researchers can develop new hypotheses and potentially identify novel interventions.
With a deep commitment to innovation and quality, our company specializes in producing high-fidelity genetic modifications and cell line development. Our extensive expertise ensures that our products meet stringent scientific standards, empowering researchers to advance their work with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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