Gene: HAGH
Official Full Name: hydroxyacylglutathione hydrolaseprovided by HGNC
Gene Summary: The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03222 | HAGH Knockout cell line (HeLa) | Human | HAGH | 1:3~1:6 | Negative | Online Inquiry |
KO03223 | HAGH Knockout cell line (HCT 116) | Human | HAGH | 1:2~1:4 | Negative | Online Inquiry |
KO03224 | HAGH Knockout cell line (HEK293) | Human | HAGH | 1:3~1:6 | Negative | Online Inquiry |
KO03225 | HAGH Knockout cell line (A549) | Human | HAGH | 1:3~1:4 | Negative | Online Inquiry |
HAGH Gene Knockout Cell Lines are specifically engineered cellular models that have been genetically modified to disrupt the expression of the HAGH (Hydroxyacid-oxoacid transhydrogenase) gene. This product enables researchers to investigate the biological roles of HAGH, including its involvement in metabolic pathways related to cellular homeostasis and the metabolism of various substrates. By providing an essential tool for elucidating the gene's function, these cell lines facilitate targeted studies ranging from basic molecular biology to complex disease modeling.
The primary mechanism of HAGH Gene Knockout Cell Lines involves the use of CRISPR/Cas9 technology, which allows for precise gene editing. This results in a complete knockout of HAGH, leading to observable phenotypic changes that can be analyzed to understand the gene's impact on cell behavior, metabolism, and response to therapeutic interventions. The ability to manipulate gene expression in this manner positions these knockout cell lines as invaluable resources for researchers focusing on metabolic disorders, drug development, and gene therapy studies.
The scientific importance of HAGH Gene Knockout Cell Lines is underscored by their wide-ranging applications in both academic and clinical research settings. These cell lines can serve as a platform for drug screening, understanding disease mechanisms, or evaluating potential therapeutic strategies targeting metabolic enzymes. Additionally, they are ideal for assessing the effects of gene disruptions on drug metabolism and side effects, making them crucial for translational research.
Compared to alternative models, HAGH Gene Knockout Cell Lines offer the advantage of specificity and reproducibility. The targeted gene knockout enhances confidence in data reliability and biological relevance, while reducing off-target effects commonly seen with less precise gene-editing techniques. Furthermore, our cell lines benefit from rigorous validation and optimization, ensuring that they meet the high standards required for high-throughput screening and experimental assays.
By investing in HAGH Gene Knockout Cell Lines, researchers, clinicians, and pharmaceutical developers gain access to robust tools that simplify complex genetic investigations and accelerate discoveries in metabolic research. Our company, known for its commitment to advancing research through innovative biological products, provides these high-quality cell lines supported by comprehensive technical assistance, ensuring maximal research impact and efficiency.
Please note that all services are for research use only. Not intended for any clinical use.
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