Gene: H4C8
Official Full Name: H4 clustered histone 8provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34229 | H4C8 Knockout cell line (HeLa) | Human | H4C8 | 1:3~1:6 | Negative | Online Inquiry |
KO34230 | H4C8 Knockout cell line (HEK293) | Human | H4C8 | 1:3~1:6 | Negative | Online Inquiry |
KO34231 | H4C8 Knockout cell line (A549) | Human | H4C8 | 1:3~1:4 | Negative | Online Inquiry |
H4C8 Gene Knockout Cell Lines are genetically engineered cell lines designed for targeted disruption of the H4C8 gene, a crucial component studied for its role in various cellular functions, including gene regulation, cell cycle progression, and stress responses. These cell lines are produced utilizing advanced CRISPR-Cas9 technology, which allows for precise editing of the genome, leading to a complete functional knockout of the H4C8 gene. This mechanism enables researchers to investigate the consequences of gene loss, thereby elucidating the biological pathways and mechanisms it influences.
The scientific importance of H4C8 Gene Knockout Cell Lines is profound, particularly in translational research and disease modeling. They serve as vital tools for studying gene function in cancer biology, neurodegenerative diseases, and metabolic disorders, presenting researchers with the ability to observe phenotypic changes associated with gene knockout and to identify potential therapeutic targets. Their application extends to the validation of drug therapies, offering insights into efficacy and mechanisms of action.
One of the notable advantages of these cell lines is their consistency and reliability, providing researchers with a powerful platform to replicate and validate findings across studies. Compared to traditional knockdown approaches, knockout cell lines offer a more robust model for genetic studies, with a complete loss of gene function rather than a reduction. This is essential for accurate biological interpretations and high-throughput screening applications.
By providing H4C8 Gene Knockout Cell Lines, we empower researchers and clinicians with the tools necessary to advance their understanding of complex biological systems and disease mechanisms. Our company specializes in developing high-quality genetic models and maintaining rigorous quality controls to ensure the accuracy and reproducibility of our products. Ultimately, investing in H4C8 Gene Knockout Cell Lines is a strategic choice for those looking to enhance their research capabilities and drive innovation in their field.
Please note that all services are for research use only. Not intended for any clinical use.
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