Gene: H4C6
Official Full Name: H4 clustered histone 6provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00015 | H4C6 Knockout cell line (PC-9) | Human | H4C6 | Negative | Online Inquiry |
H4C6 Gene Knockout Cell Lines are genetically engineered model systems in which the H4C6 gene has been inactivated or "knocked out," rendering them invaluable tools in molecular biology research. These cell lines provide researchers with a unique opportunity to study the functional roles of the H4C6 gene in various cellular contexts, thus illuminating its contributions to processes such as cell proliferation, differentiation, and apoptosis.
The mechanisms underlying the utility of H4C6 Gene Knockout Cell Lines involve the use of advanced CRISPR/Cas9 technology, which introduces precise edits into the genome. By removing or altering the H4C6 gene, these cell lines allow for the examination of signaling pathways and gene interactions without the confounding influence of the H4C6 protein. This specificity enables scientists to dissect complex biological processes and assess the implications of gene loss in a controlled environment.
In the realm of research and clinical diagnostics, the H4C6 Gene Knockout Cell Lines have significant applications, particularly in cancer biology and targeted therapy development. By understanding how the absence of the H4C6 gene influences cellular responses, researchers can develop innovative therapeutic strategies and identify potential biomarkers for diseases. Moreover, these cell lines serve as essential platforms for drug screening and toxicity studies.
A notable advantage of the H4C6 Gene Knockout Cell Lines is their high fidelity and reproducibility, which are often superior to traditional knockdown methods due to the permanent nature of gene disruption. Additionally, these cell lines are readily available, facilitating ease of integration into existing research workflows.
For researchers and clinicians seeking to unravel complex genetic interactions or develop targeted therapies, H4C6 Gene Knockout Cell Lines represent an indispensable resource that enhances the understanding of gene function and disease mechanisms. Our company prides itself on its commitment to providing high-quality, genetically engineered tools, backed by robust research and expert support, ensuring that our customers can advance their scientific inquiries with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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