Gene: H4C4
Official Full Name: H4 clustered histone 4provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34222 | H4C4 Knockout cell line (HCT 116) | Human | H4C4 | 1:2~1:4 | Negative | Online Inquiry |
KO34223 | H4C4 Knockout cell line (HEK293) | Human | H4C4 | 1:3~1:6 | Negative | Online Inquiry |
KO34224 | H4C4 Knockout cell line (A549) | Human | H4C4 | 1:3~1:4 | Negative | Online Inquiry |
H4C4 Gene Knockout Cell Lines are a specialized biological product designed for advanced genetic research and therapeutic development. These cell lines have been engineered to possess specific gene knockouts that allow for the study of gene function, regulation, and potential therapeutic targets in a controlled environment. This innovative approach enables researchers to elucidate the roles of genes in various biological processes and disease states, thereby enhancing our understanding of cellular mechanisms.
The primary mechanism of action involves targeted gene disruption through techniques such as CRISPR/Cas9 or RNA interference, facilitating precise manipulation of the genome. By creating knockout models, researchers can explore phenotypic changes associated with the loss of specific genes, providing valuable insights that are crucial for drug development, disease modeling, and functional genomics.
The scientific importance of H4C4 Gene Knockout Cell Lines lies in their vast applications across multiple fields, including cancer research, neurobiology, and immunology. They serve as invaluable tools in the identification of gene targets for novel therapies and the validation of drug candidates, streamlining the path from discovery to clinical application.
Compared to other gene knockout systems, H4C4 cell lines are notable for their reliability and reproducibility. They are meticulously characterized for genetic integrity and exhibit consistent performance across various assays, offering researchers confidence in their experimental results. Furthermore, these cell lines boast superior viability and growth rates, making them ideal for long-term studies.
For researchers and clinicians striving to advance their project goals, H4C4 Gene Knockout Cell Lines provide a robust platform that accelerates discovery while minimizing the uncertainties often associated with genetic manipulation. Our company has extensive expertise in developing and characterizing high-quality biological products, ensuring that you receive innovative solutions tailored to your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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