Gene: H4C3
Official Full Name: H4 clustered histone 3provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05129 | H4C3 Knockout cell line (HeLa) | Human | H4C3 | 1:3~1:6 | Negative | Online Inquiry |
KO05130 | H4C3 Knockout cell line (HCT 116) | Human | H4C3 | 1:2~1:4 | Negative | Online Inquiry |
KO05131 | H4C3 Knockout cell line (HEK293) | Human | H4C3 | 1:3~1:6 | Negative | Online Inquiry |
KO05132 | H4C3 Knockout cell line (A549) | Human | H4C3 | 1:3~1:4 | Negative | Online Inquiry |
H4C3 Gene Knockout Cell Lines are an innovative suite of genetically engineered cellular systems designed to facilitate the study of gene function and the role of specific proteins in cellular pathways. These cell lines have been meticulously developed using CRISPR-Cas9 technology, allowing for precise and efficient gene disruption. By targeting the H4C3 gene, these knockout cell lines serve as invaluable tools for researchers aiming to investigate the biological implications of gene loss, as well as the potential compensatory mechanisms activated in response.
The key mechanisms underlying these cell lines involve the introduction of double-strand breaks at specific genomic locations, which subsequently leads to a disruption of the gene's coding sequence. This interruption can result in the loss of protein expression, enabling scientists to study the resultant phenotypic changes. Through functional assays, researchers can gain insights into cellular processes such as proliferation, metabolism, and apoptosis, significantly enriching our understanding of cellular dynamics and disease pathology.
The scientific importance of H4C3 Gene Knockout Cell Lines is underscored by their wide-ranging applications, from basic research to therapeutic development. In clinical settings, these models can be utilized to explore potential targets for gene therapy, assess drug efficacy, and uncover biomarkers for disease. The ability to model diseases at the cellular level is pivotal for advancing personalized medicine and tailored treatment strategies.
One significant advantage of H4C3 Gene Knockout Cell Lines over traditional knockout models is their quick generation time and the enhanced specificity of CRISPR technology, allowing for more reliable and reproducible experimental outcomes. Researchers benefit from the application of these cell lines, which offer a high-throughput approach to gene functional studies with consistent and scalable results.
In an era where precision medicine is becoming the norm, the value of H4C3 Gene Knockout Cell Lines lies in their potential to unlock the complexities of genetic interactions and pathways. They provide an indispensable resource for researchers and clinicians alike, paving the way for groundbreaking discoveries in genetics and molecular biology.
Our company prides itself on its commitment to innovation and quality in the field of genetic research tools, and H4C3 Gene Knockout Cell Lines represent the forefront of our product offerings, tailored to meet the needs of both academic and clinical research communities.
Please note that all services are for research use only. Not intended for any clinical use.
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