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H2BN1 Knockout Cell Lines

Gene: H2BN1

Official Full Name: H2B.N variant histone 1provided by HGNC

Gene Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17189 H2BN1 Knockout cell line (HeLa) Human H2BN1 1:3~1:6 Negative Online Inquiry
KO17190 H2BN1 Knockout cell line (HCT 116) Human H2BN1 1:2~1:4 Negative Online Inquiry
KO17191 H2BN1 Knockout cell line (HEK293) Human H2BN1 1:3~1:6 Negative Online Inquiry
KO17192 H2BN1 Knockout cell line (A549) Human H2BN1 1:3~1:4 Negative Online Inquiry

Background

H2BN1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the H2BN1 gene, a member of the histone family involved in chromatin remodeling and gene regulation. This product serves as a critical tool for investigating the functional impacts of H2BN1 silencing on cellular processes, particularly those associated with epigenetic regulation, cell cycle control, and responses to DNA damage.

These knockout cell lines exhibit an enhanced ability to elucidate gene function through the loss of H2BN1, allowing researchers to delineate its role in various biological contexts. The mechanism behind the gene knockout involves using CRISPR/Cas9 technology, which creates double-strand breaks in the DNA sequence of H2BN1, effectively disrupting its expression. This leads to a clearer understanding of the cellular pathways affected by the absence of this gene, providing insights that can inform therapeutic strategies for diseases linked to epigenetic dysregulation.

The scientific importance of H2BN1 Knockout Cell Lines extends beyond basic research; they are invaluable in preclinical studies aimed at drug development, particularly in oncology and regenerative medicine. By understanding the pathways influenced by H2BN1, researchers can identify potential drug targets or biomarkers for disease progression.

What sets our H2BN1 Gene Knockout Cell Lines apart from alternatives is their robust validation and reproducibility in experimental conditions, paired with ease of use for downstream applications such as genomic and proteomic analyses. Furthermore, our commitment to quality ensures that each cell line is supplied with comprehensive data, including genotype validation, which addresses a common issue in research when utilizing cell lines.

For researchers and clinicians alike, our H2BN1 Gene Knockout Cell Lines represent a unique opportunity to explore foundational aspects of gene function and molecular biology. These cell lines provide significant advantages in experimental accuracy and offer a reliable platform for hypothesis-driven research.

At [Your Company Name], we leverage our expertise in molecular genetics and cell biology to deliver high-quality biological products that empower scientific innovation and discovery. Our commitment to excellence ensures that researchers have access to cutting-edge tools that drive advancements in modern bioscience.

Please note that all services are for research use only. Not intended for any clinical use.

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