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H1-4 Knockout Cell Lines

Gene: H1-4

Official Full Name: H1.4 linker histone, cluster memberprovided by HGNC

Gene Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37433 H1-4 Knockout cell line (HeLa) Human H1-4 1:3~1:6 Negative Online Inquiry
KO37434 H1-4 Knockout cell line (HCT 116) Human H1-4 1:2~1:4 Negative Online Inquiry
KO37435 H1-4 Knockout cell line (HEK293) Human H1-4 1:3~1:6 Negative Online Inquiry
KO37436 H1-4 Knockout cell line (A549) Human H1-4 1:3~1:4 Negative Online Inquiry

Background

H1-4 Gene Knockout Cell Lines represent an advanced biological tool designed to facilitate the precise study of gene function by enabling the targeted disruption of the H1-4 gene. Utilizing CRISPR-Cas9 technology, these engineered cell lines exhibit a robust knockout phenotype that aids researchers in elucidating the role of the H1-4 gene in various biological processes, including cellular regulation, differentiation, and disease mechanisms.

The key function of H1-4 Gene Knockout Cell Lines lies in their ability to create a controlled environment where the expression of the H1-4 gene is abolished, thus providing an invaluable resource for studying the gene's contributions to key metabolic pathways and signaling cascades. By removing this gene, researchers can observe consequential alterations in cellular behavior, helping to unravel the intricate networks that underlie complex biological systems.

Scientifically, these cell lines are crucial for both basic research and translational studies. They enable researchers to investigate the role of the H1-4 gene in various disease models, including cancer and genetic disorders. Furthermore, the insights gained from experiments using these cell lines can lead to the identification of potential therapeutic targets and pathways for drug development.

Compared to other gene editing technologies, such as traditional knockout methods or RNA interference, H1-4 Gene Knockout Cell Lines provide distinct advantages, including higher specificity, efficiency, and a more reproducible knockout effect. The use of CRISPR-Cas9 ensures precise editing without off-target effects, making these cell lines a superior choice for intricate genetic studies.

For researchers and clinicians, the value of H1-4 Gene Knockout Cell Lines extends beyond mere experimental utility; they embody a commitment to providing high-quality tools that enhance the understanding of gene functions and their implications in health and disease. With a focus on biological innovation, our company leverages extensive expertise in genetic engineering to deliver reliable and cutting-edge products that empower the scientific community in groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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