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Grik1 Knockout Cell Lines

Gene: Grik1

Official Full Name: glutamate receptor, ionotropic, kainate 1provided by MGI

Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01209 Grik1 Knockout cell line(4T1) Mouse Grik1 1:3~1:4 Negative Online Inquiry

Background

Grik1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of Grik1 gene functions, which plays a crucial role in glutamate transmission and synaptic plasticity in the central nervous system. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a complete knockout of the Grik1 gene, allowing researchers to investigate the gene’s contributions to various physiological and pathological processes without the effects of the wild-type allele.

The primary function of Grik1 knockout cell lines lies in their ability to mimic conditions of Grik1 gene disruption, thereby providing a valuable experimental tool for studying excitatory neurotransmission, neurodegenerative diseases, and psychiatric disorders. These cell lines facilitate detailed investigations into synaptic integrity and neurotransmitter receptor dynamics, enabling a deeper understanding of the underlying molecular mechanisms and potential therapeutic targets for conditions such as Alzheimer’s disease, schizophrenia, and epilepsy.

Scientifically, the Grik1 knockout cell lines hold significant importance in both research and clinical settings, allowing for accelerated drug discovery and development processes. These cell lines are indispensable in screening therapeutic agents, evaluating efficacy, and understanding drug interactions with the glutamatergic system. Furthermore, their use streamlines translational research efforts aimed at developing precise treatment regimens.

One of the distinct advantages of our Grik1 Gene Knockout Cell Lines is that they provide a high degree of specificity and reproducibility compared to conventional genetic manipulation approaches. Their ease of integration into high-throughput screening platforms also accelerates experimental timelines, making them more cost-effective for laboratories.

Researchers and clinicians targeting neurobiology or pharmacology will find immense value in these cell lines, as they not only bridge laboratory findings to potential clinical applications but also enhance the development of innovative treatments. Our company prides itself on its commitment to advancing research tools through cutting-edge genetic engineering and molecular biology techniques, ensuring that our products meet the highest scientific standards for accuracy and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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